Results 71 to 80 of about 29,991,200 (150)
Evolution and functional divergence of the anoctamin family of membrane proteins [PDF]
, 2010 Background: The anoctamin family of transmembrane proteins are found in all eukaryotes and consists of 10 members in vertebrates. Ano1 and ano2 were observed to have Ca(2+) activated Cl-channel activity.
Milenkovic, Vladimir M. +9 more
core +1 more source
Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]
PLoS ONE, 2015 The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo +6 more
doaj +1 more source
Update on cellular expression and function of ANO1 channels in urethral smooth muscle
The Journal of Physiology, EarlyView.Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley +1 more source
Expression of Anoctamin 1 in adult zebrafish [PDF]
, 2015 Anoctamin 1 (Ano1) codes for a calcium activated chloride channel that has recently been identified as a marker for gastrointestinal stromal tumors, as well as been shown to be selectively expressed by interstitial cells of Cajal (ICC) in the muscle ...
Brady, Clayton
core +1 more source
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +1 more source
Anoctamin 5 (ANO5) Muscle Disorders: A Narrative Review
, 2022 Anoctaminopathy-5 refers to a group of hereditary skeletal muscle or bone disorders due to mutations in the anoctamin 5 (ANO5)-encoding gene, ANO5. ANO5 is a 913-amino acid protein of the anoctamin family that functions predominantly in phospholipid ...
Soontrapa, Pannathat +3 more
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Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
Annals of Neurology, Volume 100, Issue 3, Page 547-558, September 2026.Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens +9 more
wiley +1 more source
Cloning and Heterologous Expression of Anoctamin Isoforms [PDF]
, 2013 학위논문 (석사)-- 서울대학교 치의학대학원 : 치의학과, 2013. 2. Frank Hong Yu.Anoctamin1 (Ano1) has Ca2+-activated Cl- channel (CaCC) character which has an important role in salivation.
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Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
PROTEOMICS, Volume 26, Issue 9, Page 6-23, September 2026.ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source