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Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte
American Journal of Physiology-Cell Physiology, 2014Iodide is captured by thyrocytes through the Na+/I− symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones. Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen.
Twyffels, L. +10 more
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Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction
Journal of Pediatric Surgery, 2020Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children. The pathophysiology of UPJ obstruction and the exact mechanism of pelviureteral peristalsis are poorly understood. Anoctamin-1 (ANO1), a Ca2+-activated chloride channel, has been shown to play a key role in muscle wall contractions in the ...
Manuela, Hunziker +4 more
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Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)
2022Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux that controls different physiological functions ranging from muscle contraction, fluid and hormone secretion, gastrointestinal motility, and electrical excitability.
Jorge, Arreola +5 more
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Calcium-regulated chloride channel anoctamin-1 is present in the suprachiasmatic nuclei of rats
NeuroReport, 2018Calcium-regulated chloride channel (CaCC) anoctamin-1 has been recently identified in neurons. In neurons, which express the Na-K-2Cl cotransporter, activation of CaCCs increases firing frequency, by reversion between the Cl equilibrium potential and the membrane resting potential, leading to membrane depolarization by Cl extrusion from the cell ...
Raúl, Aguilar-Roblero +7 more
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A mathematical model of the effects of anoctamin-1 loss on intestinal slow wave entrainment
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017The interstitial cells of Cajal (ICC) generate electrophysiological events called slow waves that regulate the motility of the gastrointestinal (GI) tract. Recent studies have demonstrated that the Ca2+-activated Cl- -channel, encoded by the anoctamin1 (Ano1) protein, has a major role in regulating intestinal slow waves and motility.
Anna Qian +4 more
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Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose
Cell and Tissue Research, 2012Calcium-activated chloride channels are expressed in chemosensory neurons of the nose and contribute to secretory processes and sensory signal transduction. These channels are thought to be members of the family of anoctamins (alternative name: TMEM16 proteins), which are opened by micromolar concentrations of intracellular Ca(2+).
Kristin, Dauner +4 more
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Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease
Pediatric Surgery International, 2015Interstitial cells of Cajal (ICCs) are pacemaker cells involved in facilitating neurotransmission and the generation of slow electrical waves necessary for colonic peristalsis. Their distribution has been found to be abnormal in the aganglionic and ganglionic colon in Hirschsprung's disease (HSCR) using c-kit-labelling.
David, Coyle +4 more
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Dilated cardiomyopathy in patients with mutations in anoctamin 5
International Journal of Cardiology, 2013Karim Wahbi, A Behin, F Leturcq
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