Results 181 to 190 of about 27,267,955 (206)

Salinity and prolactin regulate anoctamin 1 in the model teleost, Fundulus heteroclitus.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology
To maintain internal ion balance in marine environments, teleost fishes leverage seawater (SW)-type ionocytes to actively secrete Na+ and Cl- into the environment.
Jason P. Breves, Mariana A Posada, Yixuan T. Tao, C. Shaughnessy   +3 more
semanticscholar   +1 more source

Regulation of Branchial Anoctamin 1 Expression in Freshwater- and Seawater-Acclimated Japanese Medaka, Oryzias latipes.

Journal of Experimental Zoology Part A Ecological and Integrative Physiology
In euryhaline teleosts, the cystic fibrosis transmembrane conductance regulator (CFTR) in seawater (SW)-type chloride cells facilitates apical Cl- secretion for SW adaptation, while alternative Cl- excretion pathways remain understudied.
N. Konno, Ayane Togashi, Hiroshi Miyanishi, M. Azuma, T. Nakamachi, Kouhei Matsuda   +5 more
semanticscholar   +1 more source

Regulation of the Ca2+-activated chloride channel Anoctamin-1 (TMEM16A) by Ca2+-induced interaction with FKBP12 and calcineurin.

Cell Calcium, 2020
Chloride fluxes through the calcium-gated chloride channel Anoctamin-1 (TMEM16A) control blood pressure, secretion of saliva, mucin, insulin, and melatonin, gastrointestinal motility, sperm capacitation and motility, and pain sensation. Calcium activates
Alfredo Sánchez-Solano, Nancy Corral, Guadalupe Segura-Covarrubias, M. Guzmán-Hernández, I. Aréchiga-Figueroa, S. Cruz-Rangel, P. Pérez-Cornejo, J. Arreola   +7 more
semanticscholar   +1 more source

Down-regulation of miR-9 promotes epithelial mesenchymal transition via regulating anoctamin-1 (ANO1) in CRC cells.

Cancer Genetics, 2019
MicroRNA-9 (miR-9) has been reported to play a suppressive or promoting role according to cancer type. In this study, we investigated the effects of anoctamin-1 (ANO1) and miR-9 on colorectal cancer (CRC) cell proliferation, migration, and invasion and ...
Young Ran Park, Soo-Teik Lee, Se Lim Kim, S. Zhu, Minnkyong Lee, S. Kim, I. Kim, Seung Ok Lee, S. Seo, Sang Wook Kim   +9 more
semanticscholar   +1 more source

EXPRESSION OF ANOCTAMIN-1 IN HUMAN GASTROINTESTINAL TRACT DURING EMBRYONIC AND FETAL DEVELOPMENT

AFMN Biomedicine
Anoctamin 1 (ANO1, TMEM16A) is a transmembrane protein belonging to the ANO family, with a role in the formation of calcium-activated chloride channels (CaCC).
Vladimir Petrovic, A. Veličkov, Marko Jović, Julija Radenković, B. Kundalić, D. Miljković, V. Radovanović, G. Radenković   +7 more
semanticscholar   +1 more source

Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity.

Bioorganic chemistry (Print), 2020
Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources.
N. Bản, L. Trường, Tran Van Tiep, Duong Thi Hai Yen, V. V. Doan, N. X. Nhiem, Yohan Seo, W. Namkung, S. Kim, B. H. Tai, P. Kiem   +10 more
semanticscholar   +1 more source

Calcium-regulated chloride channel anoctamin-1 is present in the suprachiasmatic nuclei of rats

NeuroReport, 2018
Calcium-regulated chloride channel (CaCC) anoctamin-1 has been recently identified in neurons. In neurons, which express the Na-K-2Cl cotransporter, activation of CaCCs increases firing frequency, by reversion between the Cl equilibrium potential and the membrane resting potential, leading to membrane depolarization by Cl extrusion from the cell ...
Raúl, Aguilar-Roblero, Adriana, Mejía-López, Dominique, Cortés-Pedroza, José L, Chavez-Juárez, Miguel A, Gutierrez-Monreal, Gabriela, Domínguez, Paula, Vergara, José, Segovia   +7 more
openaire   +2 more sources

A mathematical model of the effects of anoctamin-1 loss on intestinal slow wave entrainment

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017
The interstitial cells of Cajal (ICC) generate electrophysiological events called slow waves that regulate the motility of the gastrointestinal (GI) tract. Recent studies have demonstrated that the Ca2+-activated Cl- -channel, encoded by the anoctamin1 (Ano1) protein, has a major role in regulating intestinal slow waves and motility.
Anna Qian, Shawn Means, Leo K. Cheng, James Sneyd, Peng Du   +4 more
openaire   +2 more sources

Anoctamin‐1 Expression at the Mitochondrial Membrane of Pulmonary Artery Endothelial Cells

The FASEB Journal, 2019
Anoctamin‐1 (Ano1) is a calcium‐activated chloride channel that can regulate cell proliferation and cell cycle in endothelial cells (ECs). According to a recent proteomics study, Ano1 interacts with mitochondrial proteins in addition to plasma‐membrane ...
M. Cypress, Stephanie M. Adaniya, Yuta Suzuki, R. Clements, Jin O-Uchi, B. Jhun, G. Choudhary   +6 more
semanticscholar   +1 more source

Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose

Cell and Tissue Research, 2012
Calcium-activated chloride channels are expressed in chemosensory neurons of the nose and contribute to secretory processes and sensory signal transduction. These channels are thought to be members of the family of anoctamins (alternative name: TMEM16 proteins), which are opened by micromolar concentrations of intracellular Ca(2+).
Kristin, Dauner, Judith, Lissmann, Semir, Jeridi, Stephan, Frings, Frank, Möhrlen   +4 more
openaire   +2 more sources