Results 71 to 80 of about 21,238,471 (180)
Anoctamin 5 (ANO5) Muscle Disorders: A Narrative Review
, 2022 Anoctaminopathy-5 refers to a group of hereditary skeletal muscle or bone disorders due to mutations in the anoctamin 5 (ANO5)-encoding gene, ANO5. ANO5 is a 913-amino acid protein of the anoctamin family that functions predominantly in phospholipid ...
Soontrapa, Pannathat +3 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington +4 more
wiley +1 more source
TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels
Molecular & Cellular Proteomics, 2011 TMEM16A/anoctamin-1 has been identified as a protein with the classic properties of a Ca(2+)-activated chloride channel. Here, we used blue native polyacrylamide gel electrophoresis (BN-PAGE) and chemical cross-linking to assess the quaternary structure of the mouse TMEM16A(a) and TMEM16A(ac) splice variants as well as a genetically concatenated ...
Fallah, Ghada +5 more
openaire +2 more sources
Validation of splice altering morpholino knockdown of anoctamin 1
, 2015 Morpholino oligonucleotides (MO) are commonly used to reduce gene expression. MO selectivity is determined by selection of a unique oligonucleotide sequence in the target of interest Suitable targets for splice altering MO are at an intron-exon ...
Denora, Maxwell
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley +1 more source
Histological and histochemical study of effect of dietary fibre in motility of stomach in male mice
Journal of the Pakistan Medical AssociationObjective: To investigate the relationship between dietary fibres and muscularis externa layer. Method: The experimental study was conducted at the Anatomy Department of the College of Medicine, Al- Nahrain University, Iraq, from November 2020 to April ...
Khulood Ayad Majeed +2 more
doaj +1 more source
Folia Morphologica, 2023 BACKGROUND: Interstitial cells of Cajal (ICC) are widely distributed in human gastrointestinal (GI) tract, especially in the layer of muscularis externa between neurons and smooth muscles.
A. Al-Ahmadi +4 more
doaj +1 more source
Update on cellular expression and function of ANO1 channels in urethral smooth muscle
The Journal of Physiology, EarlyView.Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley +1 more source
TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation
Biomedicine & Pharmacotherapy, 2020 Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment of coronary spasmodic disorders.TMEM16A-encoded anoctamin 1 (ANO1), a Ca2+ activated Cl- channel ...
Guijin, Ma +7 more
openaire +2 more sources
Anoctamin 6 regulates C2C12 myoblast proliferation.
, 2014 Anoctamin 6 (Ano6) belongs to a conserved gene family (TMEM16) predicted to code for eight transmembrane proteins with putative Ca2+-activated chloride channel (CaCC) activity.
Andrew Mariano +13 more
core +1 more source