Results 81 to 90 of about 21,238,471 (180)
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
European Journal of Pain, Volume 30, Issue 6, July 2026.ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian +8 more
wiley +1 more source
Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics
Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu +3 more
wiley +1 more source
Cloning and Heterologous Expression of Anoctamin Isoforms [PDF]
, 2013 학위논문 (석사)-- 서울대학교 치의학대학원 : 치의학과, 2013. 2. Frank Hong Yu.Anoctamin1 (Ano1) has Ca2+-activated Cl- channel (CaCC) character which has an important role in salivation.
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Anoctamin 2/TMEM16B: A calcium-activated chloride channel in olfactory transduction [PDF]
, 2012 In vertebrate olfactory transduction, a Ca2+-dependent Cl- efflux greatly amplifies the odorant response. The binding of odorants to receptors in the cilia of olfactory sensory neurons activates a transduction cascade that involves the opening of cyclic ...
Pifferi S., Cenedese V., Menini A.
core +1 more source
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +1 more source
Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]
PLoS ONE, 2015 The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo +6 more
doaj +1 more source
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández +5 more
wiley +1 more source
Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær +4 more
wiley +1 more source