Results 31 to 40 of about 29,991,200 (150)

Anoctamin-5-Myopathie : Klinik, Histologie und Proteom einer Hallenser Kohorte [PDF]

, 2023
Die Anoctamin-5-Myopathie ist eine der häufigsten Ursachen für hereditäre Myopathien in Nordeuropa. Klinisch und histologisch zeigt die Erkrankung ein äußerst heterogenes Bild. Ursächlich sind rezessive Mutationen im Anoctamin-5-Gen.
Richert, Caroline
core   +1 more source

Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases [PDF]

, 2018
Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Kevin J. Hendargo (5007257), Ye, Zachary S, Zachary S. Ye, Arturo Medrano-Soto, Daniel McLaughlin, Milton H. Saier, Kevin J Hendargo, Zachary S. Ye (5007251), Daniel McLaughlin (5007254), Hendargo, Kevin J, McLaughlin, Daniel, Moreno-Hagelsieb, Gabriel, Medrano-Soto, Arturo, Milton H Saier, Gabriel Moreno-Hagelsieb, Zachary S Ye, Saier, Milton H, Arturo Medrano-Soto (1997), Gabriel Moreno-Hagelsieb (578), Milton H. Saier Jr. (205181), Kevin J. Hendargo   +20 more
core   +4 more sources

Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f

Gastro Hep Advances, 2022
Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber, Ines Cabrita, Karl Kunzelmann   +2 more
doaj   +1 more source

Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmission

, 2012
We investigated the cellular distribution of the calcium-activated chloride channel (CaCC), anoctamin 1, in the urethra of mice, rats, and sheep by both immunofluorescence and PCR. We studied its role in urethral contractility by examining the effects of
Sancho González, María, Triguero Robles, Domingo, García Pascual, María De Los Ángeles   +2 more
core   +2 more sources

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Nature Communications, 2017
Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse ...
Florence Sonneville, Manon Ruffin, Christelle Coraux, Nathalie Rousselet, Philippe Le Rouzic, Sabine Blouquit-Laye, Harriet Corvol, Olivier Tabary   +7 more
doaj   +1 more source

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Frontiers in Bioscience-Landmark, 2022
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu, Meihan Chen, Qingwen Xu, Cheng Xue, Lili Fu, Kun Ling, Jinghua Hu, Changlin Mei   +7 more
doaj   +1 more source

Generation of Muscle Tone in the Murine Internal Anal Sphincter by Anoctamin 1 [PDF]

, 2015
The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent.
Kirchoff, Ileah
core   +2 more sources

Differential expression of anoctamin 1 in human epithelial ovarian cancer.

, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2,
Shahan Mamoor
core   +1 more source

Chloride – The Underrated Ion in Nociceptors

Frontiers in Neuroscience, 2020
In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has received less attention.
Bettina U. Wilke, Kai K. Kummer, Michael G. Leitner, Michaela Kress   +3 more
doaj   +1 more source