Results 41 to 50 of about 29,991,200 (150)

Validation of splice altering morpholino knockdown of anoctamin 1 [PDF]

, 2015
Morpholino oligonucleotides (MO) are commonly used to reduce gene expression. MO selectivity is determined by selection of a unique oligonucleotide sequence in the target of interest Suitable targets for splice altering MO are at an intron-exon ...
Denora, Maxwell
core   +1 more source

Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line

Stem Cell Research, 2022
The Transmembrane member 16A (TMEM16A), also known as anoctamin-1 (ANO1), is a calcium-activated chloride channel present in the airway epithelium. It is known to be involved in the apical chloride secretion indicating that TMEM16A could be addressed for
Mark-Christian Jaboreck, Jonathan Lukas Lühmann, Mia Mielenz, Frauke Stanke, Gudrun Göhring, Ulrich Martin, Ruth Olmer, Sylvia Merkert   +7 more
doaj   +1 more source

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]

PLoS ONE, 2013
Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon, Sun Sook Paik, Myung-Hoon Chun, Uhtaek Oh, In-Beom Kim   +4 more
doaj   +1 more source

Anoctamin 6 regulates C2C12 myoblast proliferation. [PDF]

, 2014
Anoctamin 6 (Ano6) belongs to a conserved gene family (TMEM16) predicted to code for eight transmembrane proteins with putative Ca2+-activated chloride channel (CaCC) activity.
Andrew Mariano, Lixia Zhao, Lixia Zhao (174165), Sadia Mohsin, Audrey Torcaso (541543), Audrey Torcaso, Piming Zhao (439983), Andrew Mariano (541544), Renzhi Han (276195), Renzhi Han, Sadia Mohsin (541545), Piming Zhao, Li Xu, Li Xu (108702)   +13 more
core   +1 more source

Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2022
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
doaj   +1 more source

Effects of protein diet on expression of Anoctamin1 of Cajal cell in the nervous plexus of the stomach in male mice

Journal of the Pakistan Medical Association
Objective: To determine the association between a protein-rich diet and the expression of anoctamin 1 in Interstitial cells of Cajal within the muscle layer of the stomach wall in male mice.
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hiba Majed Rasol   +2 more
doaj   +1 more source

Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Acta Pharmaceutica Sinica B, 2021
Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu   +11 more
doaj   +1 more source

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

, 2014
Polycystic kidney diseases are characterized by multiple bilateral renal cysts that gradually enlarge and lead to a decline in renal function. Cyst enlargement is driven by transepithelial chloride secretion, stimulated by enhanced levels of cyclic ...
Faria, Diana, Kunzelmann, Karl, Schreiber, Rainer, Eckardt, Kai-Uwe, Buchholz, Bjoern, Schley, Gunnar   +5 more
core   +1 more source

Novel mutations in the anoctamin 5 gene ( ANO5 ) associated with limb‐girdle muscular dystrophy 2L [PDF]

, 2013
Introduction: We present a Jordanian man with the typical LGMD 2L phenotype of early, asymmetric quadriceps weakness and subsequent biceps brachii weakness. Methods: Case report.
Little, Ann A., Mckeever, Paul E., Gruis, Kirsten L.   +2 more
core   +1 more source

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Nature Communications, 2019
The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells.
Anamika Dayal, Shu Fun J. Ng, Manfred Grabner   +2 more
doaj   +1 more source