Results 111 to 120 of about 5,018 (188)

Anoctamin‐1 channel localization in excitable domains of the heart (893.23)

The FASEB Journal, 2014
Calcium‐activated chloride (Cl Ca ) currents are widely distributed in cardiac tissues and have been implicated to play a role in cardiac physiology and pathophysiology. Anoctamin‐1 (Ano1) is a membrane protein that functions as a Cl Ca channel and has ...
Fiona Britton, Kate O'Driscoll, William Hatton   +2 more
openaire   +1 more source

Utilisation of Deep Neural Networks for Estimation of Cajal Cells in the Anal Canal Wall of Patients with Advanced Haemorrhoidal Disease Treated by LigaSure Surgery

Cells
Interstitial cells of Cajal (ICCs) play a key role in gastrointestinal smooth muscle contractions, but their relationship with anal canal function in advanced haemorrhoidal disease (HD) remains poorly understood. This study uses deep neural network (DNN)
Inese Fišere, Edgars Edelmers, Šimons Svirskis, Valērija Groma   +3 more
doaj   +1 more source

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

Molecular Cancer, 2017
TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang, Liang Zou, Ke Ma, Jiankun Yu, Huizhe Wu, Minjie Wei, Qinghuan Xiao   +6 more
doaj   +1 more source

The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila. [PDF]

, 2016
Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood.
Abuin, Alloui, Barbagallo, Benton, Brand, Brotz, Chen, Chen, Cho, Croset, Flouris, Gallio, Goris, Kang, Klein, Ni, Palkar, Parks, Pfeiffer, Port, Rytz, Sengupta, Shen, Silbering, Vriens, Zhang   +25 more
core   +3 more sources

HCO3- transport through anoctamin/transmembrane protein ANO1/TMEM16A, in pancreatic acinar cells, regulates luminal pH [PDF]

, 2016
The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Han, Yanfeng, Shewan, Annette M., Thorn, Peter   +2 more
core   +1 more source

Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function

Cellular Physiology and Biochemistry, 2018
Background/Aims: Calcium-activated chloride channels (CaCCs) regulate numerous physiological processes including cell proliferation, migration, and extracellular matrix secretion. T16Ainh-A01 and CaCCinh-A01 are selective inhibitors of CaCCs.
Xiang-qin Tian, Ke-tao Ma, Xian-wei Wang, Yang Wang, Zhi-kun Guo, Jun-qiang  Si   +5 more
doaj   +1 more source

P2X4 receptor function in the nervous system and current breakthroughs in pharmacology [PDF]

, 2017
ATP is a well-known extracellular signalling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the crystal structure of ...
Abdelrahman, Acuna-Castillo, Agresti, Allsopp, Amadio, Antonio, Asatryan, Asatryan, Asatryan, Ase, Balazs, Banke, Bardoni, Basbaum, Baxter, Bernier, Bhattacharya, Biber, Bintig, Bo, Bobanovic, Boumechache, Bowler, Browne, Buell, Burnstock, Burnstock, Cao, Cardoso, Cham, Chung, Clarke, Coddou, Coddou, Coddou, Cohen, Coull, Davies, de Rivero Vaccari, Di Virgilio, DiSabato, Dixon, Egan, Farber, Ferrini, Fischer, Franke, Franklin, Franklin, Fumagalli, Gao, Garcia-Guzman, Gofman, Gofman, Guo, Hattori, He, Hernandez-Olmos, Horvath, Horvath, Huang, Huynh, Idzko, Igawa, Inoue, Ito, Jabs, Jarvis, Jelinkova, Jo, Joers, Jones, Kawate, Kerr, Kettenmann, Khakh, Khakh, Khakh, Khakh, Khakh, Khoja, Kimpel, Kobayashi, Krause, Krůšek, Kukley, Laing, Lalo, Lalo, Le, Li, Li, Li, Luo, Lê, Mapplebeck, Masuda, Matsumura, Miklavc, Miller, Nagata, Nasu-Tada, Neher, Nicke, North, Nörenberg, Oesterle, Ostrovskaya, Ousingsawat, Ozaki, Pelegrin, Popova, Popova, Potula, Priel, Qureshi, Ransohoff, Raouf, Robinson, Rokic, Royle, Rubio, Saijo, Samways, Samways, Sathanoori, Saul, Schwab, Shinozaki, Shrivastava, Silberberg, Sim, Sim, Sorge, Soto, Soto, Stojilkovic, Stojilkovic, Stokes, Stokes, Surprenant, Tan, Tian, Toulme, Toulme, Toulme, Toyomitsu, Trang, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Ulmann, Ulmann, Ulmann, Vavra, Vazquez-Villoldo, Virginio, Wes, Wheeler-Schilling, Wildman, Wixey, Wyatt, Wyatt, Xiong, Xu, Yamamoto, Yamamoto, Yamashita, Yang, Yardley, Zarei, Zemkova   +174 more
core   +2 more sources

Differential expression of anoctamin 1 in human epithelial ovarian cancer.

, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of ...
openaire   +2 more sources

Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. [PDF]

, 2013
BackgroundThe aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression.
Boutros, Paul C, Chamankhah, Mahmood, Eftekharpour, Eftekhar, Fehlings, Michael G, Karimi-Abdolrezaee, Soheila, San-Marina, Serban   +5 more
core   +3 more sources

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

Cellular Physiology and Biochemistry, 2014
Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco, Cristina Cosentino, Laura Sirna, Roberta Romano, Silvia Cursano, Alessandra Mongia, Giampaolo Pompeo, Julie di Bernardo, Claudio Ceccarelli, Giovanni Tallini, Kerry J. Rhoden   +10 more
doaj   +1 more source