Results 91 to 100 of about 431 (145)

ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression

International Journal of Oncology, 2012
Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of Janus kinase and the signal transducer and activation of transcription (Jak-STAT) pathway. SOCS-1 is known to be silenced by aberrant promoter methylation in human hepatocellular carcinoma (HCC) during early tumorigenesis, therefore, a strategy to restore SOCS1 expression can be ...
Ji-Young, Jang, Yoon-Kyung, Jeon, Choong-Eun, Lee, Chul-Woo, Kim   +3 more
openaire   +3 more sources

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Cancer Communications, Volume 45, Issue 7, Page 722-727, July 2025.
Lea Järke, Saskia Weber‐Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer   +15 more
wiley   +1 more source

Cloning of Adenine Nucleotide Translocase 2 (ANT2) and Its Expression Under Low Temperature Stress in the Mud Crab,Scylla paramamosain

, 2014
腺苷酸转移酶(AnT)是线粒体中最丰富的蛋白质之一,其主要作用是介导AdP/ATP在细胞质和线粒体基质之间的运输.为探讨该基因在拟穴青蟹(SCyllA PArAMAMOSAIn)低温适应中的作用,采用反转录PCr(rT-PCr)、CdnA末端快速扩增技术(rACE)等技术,从拟穴青蟹中获得了AnT2的CdnA全长序列,并运用实时荧光定量PCr(QPCr)技术检测了AnT2在不同组织和不同温度下的表达谱.该序列全长1 348bP,开放阅读框(Orf)为930bP,编码309个氨基酸残基.同源分析显示 ...
叶海辉, 黄辉洋, 巩杰, 林思恒, 于坤   +4 more
core  

Effects of different temperature and salinity on the expression of adenine nucleotide translocase 2(ANT2) m RNA in the mud crab, Scylla paramamosain

, 2014
采用Q rT-PCr技术,对不同温度(10℃,15℃,20℃,25℃)以及低温(10℃,15℃)和盐度(10,35)联合作用下拟穴青蟹(SCyllA PArAMAMOSAIn)(甲壳长3.7~5.8 CM,体质量80~100 g)AnT2基因的表达进行了检测。结果表明:在4个温度下肝胰腺、肌肉、鳃中AnT2基因表达量依次为低、中、高,存在组织表达特异性。随着温度降低,AnT2基因总体上趋低表达,但在15℃时AnT2基因在肌肉(1~12 H)和鳃中均显著高于20 ...
叶海辉, 黄辉洋, 黄陈翠, 巩杰, 于坤   +4 more
core  

Apigenin enhances Apo2L/TRAIL-induced apoptosis by inhibiting ANT2 in LNCaP cells.

, 2013
LNCaP cells were transfected with siANT2 or siCtrl and were incubated for 48 hr. A, ANT2 mRNA was quantified by real-time RT-PCR and normalized by GAPDH. B, Protein levels of DR5 and β-actin were analyzed by Western blotting.
Tomoyuki Taniguchi (337403), Toshiyuki Sakai (309632), Tsuneharu Miki (337405), Yosuke Iizumi (337402), Masakatsu Oishi (337401), Wakana Goi (337404)   +5 more
core   +1 more source

B-cell translocation gene 2: expression in the rat ovary and potential association with adenine nucleotide translocase 2 in mitochondria.

, 2013
The B-cell translocation gene 2 (Btg2) is an anti-proliferative tumor suppressor gene that behaves as a transcriptional regulator. The present study investigated gonadotropin induction of Btg2 in the rat ovary and the mechanism of Btg2 action as a ...
Seo, YW, Kim, SG, Park, JI, Baek, MW, Chun, SY, Lim, IK, Park, TJ   +6 more
core   +1 more source

Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation

Abstract Myocardial ischemia-reperfusion (IR) injury is the most common type of heart disease. IR-disrupted mitochondrial homeostasis affects heart energy metabolism and function, but the mechanism remains poorly understood.
Simeng Li, Siman Shen, Yongfang Hong, Kun Ding, Suyun Chen, Jianning Chen, Changsen Wang, Yaofeng Wen, Guixi Mo, Lili Yu, De-Li Shi, Liangqing Zhang   +11 more
openaire   +1 more source

Identification of ANT2 as a Druggable Target for Endocrine-Resistant ERα-Positive Breast Cancer

International Journal of Molecular Sciences
Endocrine therapy is the mainstay for estrogen receptor (ER) α-positive breast cancer (BC), yet many patients display acquired resistance. We then screened natural compounds using human ERα-positive BC cells and identified perillyl alcohol (POH), a monoterpene from perilla, that reduces ERα protein levels.
Erika Iguchi, Motoki Watanabe, Kaito Kobayashi, Shogen Boku, Wataru Nishio, Chikage Kato, Midori Morita, Koichi Sakaguchi, Michihiro Mutoh, Tomoshi Kameda, Yasuto Naoi   +10 more
openaire   +1 more source

Analysis of Anthocyanin-Less 2 Diversity in Barley Reveals a Specific Allele to Cause Purple-Colored Grains

The purple color of the barley (Hordeum vulgare L.) grain is attributed to anthocyanins which are beneficial for human health. Synthesis of these pigments in both grain and vegetative tissues is controlled by ANT1 and ANT2 that belong to the families ...
Kovaleva, Olga N., Gerasimova, Sophia V., Zakhrabekova, Shakhira, Hertig, Christian W., Kumlehn, Jochen, Hansson, Mats, Zedgenizova, Varvara D., Shoeva, Olesya Y., Kukoeva, Tatjana V., Hoffie, Iris, Vasiliev, Gennady V., Khlestkina, Elena, Egorova, Anastasiya A., Vasiliev, Gennady V.,, Khlestkina, Elena,, Kumlehn, Jochen,, Kovaleva, Olga N.,, Hoffie, Iris,, Hertig, Christian W.,, Gerasimova, Sophia V.,, Kukoeva, Tatjana V.,, Shoeva, Olesya Y.,, Zedgenizova, Varvara D.,, Hansson, Mats,, Egorova, Anastasiya A.,, Zakhrabekova, Shakhira,, Lund University.   +26 more
core   +1 more source

Abstract 3733: Adenine nucleotide translocase2 mediates 18F-FDG uptake in dedifferentiated thyroid cancer

, 2017
Objectives: 18F-fluorodeoxyglucose (FDG), an analogue of glucose, provides valuable functional information based on the increased glucose uptake and glycolysis in malignant tumor cells.
Young Joo Park, Sun Wook Cho, Seock-Jin Chung, Mi Jeong Kim, June-Key Chung, Chul-Hee Lee, Hyewon Youn, Cho Rong Park, Ha Kim, Keon Wook Kang   +9 more
core   +1 more source