Results 151 to 160 of about 1,043,535 (340)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists [PDF]

, 2023
Joanne C. Clark, Eleyna M. Martin, Luis A. Morán, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk‐Peter Herten, Michael G. Tomlinson, Ángel Galindo García, Steve P. Watson   +16 more
openalex   +1 more source

Glucocorticoid antagonists

FEBS Letters, 1987
Agarwal, M.K., Hainque, B., Moustaid, N., Lazer, G.   +3 more
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific

, 2007
Floride Niyuhire, Stephen A. Varvel, Andrew Thorpe, Rene J. Stokes, Jenny L. Wiley, Aron H. Lichtman   +5 more
openalex   +1 more source

Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist [PDF]

, 2009
Deborah Watson, Mark E. Stanton
openalex   +1 more source

Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences

, 2021
Xing Zhang, Benjamin W. Harding, Dina Aggad, Damien Courtine, Jia‐Xuan Chen, Nathalie Pujol, Jonathan J. Ewbank   +6 more
openalex   +1 more source

In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist [PDF]

, 2022
Kristina Puls, Aina-Leonor Olivé-Marti, Szymon Pach, Birgit Pinter, Filippo Erli, Gerhard Wolber, Mariana Spetea   +6 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Pharmacological Properties of ABT-239 [4-(2-{2-[(2 R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties

, 2005
Timothy A. Esbenshade, Gerard B. Fox, Kathleen M. Krueger, Thomas R. Miller, Chae Hee Kang, Lynne Denny, David G. Witte, Betty Yao, Liping Pan, Jill M. Wetter, Kennan C. Marsh, Youssef L. Bennani, Marlon Cowart, James P. Sullivan, Arthur A. Hancock   +14 more
openalex   +1 more source