Results 241 to 250 of about 1,005,341 (342)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Effect of Aldosterone Antagonist (SC 9420) on Periodic Paralysis [PDF]

, 1962
Shigeo Okinaka, Nakaaki Ohsawa, KAZUO SHIZUME, Kenji Motohashi, Takuo Fujita, Shoichiro Murakawa, Fukashi Matsuzaki, Hirotoshi Morii, Toru Uchikawa   +8 more
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Spinal excitability is enhanced by transcranial magnetic stimulation of the motor cortex in children and adolescents. [PDF]

Clin Neurophysiol Pract
Marttinen Rossi EJ, Nevalainen P, Toppila J, Mäenpää H, Guzmán-López J, Piitulainen H, Lauronen L.   +6 more
europepmc   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Antagonism of 5-HT7 Receptors as a Promising Target for Gastric Cancer via Apoptotic Pathway. [PDF]

J Biochem Mol Toxicol
Cinar I, Dincer B, Cadirci E, Kara S, Yildirgan MI, Halici Z, Palabiyik-Yucelik SS.   +6 more
europepmc   +1 more source

Serotonin Antagonists in Experimental and Clinical “Dumping”

, 1962
Lloyd Johnson, Richard D. Sloop, John E. Jesseph, Henry N. Harkins   +3 more
openalex   +2 more sources

IL-1 receptor antagonist production by isolated mononuclear cells is a better indicator of bioincompatibility of hemodialysis membranes than that by stimulated whole blood [PDF]

, 2000
Eigler, A., Endres, S., Schiffl, Helmut, Toepfer, Marcel, Tuma, E.   +4 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

The impact of season, temperature, and direct normal irradiance on IVF pregnancy outcomes: a retrospective cohort study. [PDF]

Int J Biometeorol
Wang C, Chen J, Lin Z, Shi L, Ruan Q, Long J, Lao Y, Niu X.   +7 more
europepmc   +1 more source