Results 71 to 80 of about 147,258 (352)

Is anterior cingulate cortex necessary for cognitive control? [PDF]

Brain, 2005
Functional neuroimaging studies in normal humans suggest that dorsal anterior cingulate cortex (dACC) plays an important role in cognitive control. This brain area is reliably activated when tasks require the ongoing adjustment of the allocation of attention.
Lesley K. Fellows, Martha J. Farah
openaire   +3 more sources

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Positive Allosteric Modulator of GABA Lowers BOLD Responses in the Cingulate Cortex. [PDF]

PLoS ONE, 2016
Knowledge about the neural underpinnings of the negative blood oxygen level dependent (BOLD) responses in functional magnetic resonance imaging (fMRI) is still limited.
Susanna A Walter, Mikael Forsgren, Karin Lundengård, Rozalyn Simon, Maritha Torkildsen Nilsson, Birgitta Söderfeldt, Peter Lundberg, Maria Engström   +7 more
doaj   +1 more source

A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

bioRxiv, 2018
We investigated afferent inputs from all areas in the frontal cortex (FC) to different subregions in the rostral anterior cingulate cortex (rACC). Using retrograde tracing in macaque monkeys, we quantified projection strength by counting retrogradely ...
Wei-jun Tang, S. Jbabdi, Ziyi Zhu, M. Cottaar, Giorgia Grisot, Julia F. Lehman, A. Yendiki, S. Haber   +7 more
semanticscholar   +1 more source

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

Advanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang, Xue‐Jing Lu, Hui‐Juan Zhang, Zhao‐Xing Wei, Ya‐Zhuo Kong, Yi‐Heng Tu, Gian Domenico Iannetti, Li Hu   +7 more
wiley   +1 more source

The Role of Anterior Cingulate Cortex in the Affective Evaluation of Conflict [PDF]

Journal of Cognitive Neuroscience, 2017
AbstractAn influential theory of ACC function argues that this brain region plays a crucial role in the affective evaluation of performance monitoring and control demands. Specifically, control-demanding processes such as response conflict are thought to be registered as aversive signals by ACC, which in turn triggers processing adjustments to support ...
Braem, Senne, King, Joseph, Korb, Franziska, Krebs, Ruth, Notebaert, Wim, Egner, Tobias   +5 more
openaire   +4 more sources

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source

Cross-sectional Associations of Fatigue with Cerebral β-Amyloid in Older Adults at Risk of Dementia

Frontiers in Medicine, 2017
Fatigue is a common symptom in the elderly and has also been associated with impaired cognition in older adults. Hence, we sought to explore the cross-sectional relationship between fatigue and cerebral β-amyloid (Aβ) in 269 elderly individuals reporting
Claudie Hooper, Philipe De Souto Barreto, Philipe De Souto Barreto, Nicola Coley, Nicola Coley, Matteo Cesari, Matteo Cesari, Pierre Payoux, Pierre Payoux, Anne Sophie Salabert, Anne Sophie Salabert, Sandrine Andrieu, Sandrine Andrieu, Sandrine Andrieu, Bruno Vellas, Bruno Vellas, for the MAPT/DSA Study Group   +16 more
doaj   +1 more source

GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness

Brain : a journal of neurology, 2019
Peripheral nerve injury-induced neuropathic pain has both sensory discriminative and affective features. Juarez-Salinas et al. report that transplanting embryonic GABAergic progenitor cells from the medial ganglionic eminence into the rostral anterior ...
Dina L Juarez-Salinas, J. Braz, A. Etlin, S. Gee, V. Sohal, A. Basbaum   +5 more
semanticscholar   +1 more source