Results 121 to 130 of about 2,661,021 (354)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Anterior segment changes following intravitreal bevacizumab injection for treatment of neovascular glaucoma [PDF]

, 2011
MI Canut1, A Alvarez2, J Nadal3, R Abreu4, JA Abreu5, JS Pulido61Glaucoma Section, 2Barraquer Ophthalmology Centre, 3Retina and Vitreous Unit, Macula Section, Institut Universitari Barraquer, Universidad Autonoma de Barcelona, Barcelona, Spain; 4Retina ...
Pulido JS, Abreu R, Alvarez A, Abreu JA, Canut MI, Nadal J   +5 more
core  

Evaluation of the Changes in Anterior Segment Morphology After Laser Peripheral Iridotomy Through One-Year Follow-Up [PDF]

, 2014
Objectives: To evaluate the long-term changes in anterior segment morphology after laser peripheral iridotomy (LPI) in eyes with primary angle-closure suspect (PACS), primary angle closure (PAC), and primary angle-closure glaucoma (PACG) using ...
Ahmet Ağaçhan, Umut Onur, Ulviye Yiğit, Yakup Acet   +3 more
core   +1 more source

Outcomes of Repeat Deep Anterior Lamellar Keratoplasty in Keratoconus: Case Series

Clinical Ophthalmology
Omar Kirat,1 Rafah Fairaq,1 Mohammed AlMutlak,1 Raneem S AlQahtani,2 Ghadah A AlHussein,2 Sara AlHilali1 1Anterior Segment Division, King Khaled Eye Specialist Hospital and Research Center, Riyadh, Saudi Arabia; 2Surgery Department, Aldiriyah Hospital ...
Kirat O, Fairaq R, AlMutlak M, AlQahtani RS, AlHussein GA, AlHilali S   +5 more
doaj  

The variability of corneal and anterior segment parameters in keratoconus.

Contact lens & anterior eye : the journal of the British Contact Lens Association, 2016
PURPOSE To analyse, describe and test diverse corneal and anterior segment parameters in normal and keratoconic eyes to better understand the geometry of the keratoconic cornea.
Enric Mas-aixala, J. Gispets, N. Lupón, G. Cardona   +3 more
semanticscholar   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Gentian violet (GV) ink associated reaction in a case of preloaded Descemet membrane endothelial keratoplasty: Case report

American Journal of Ophthalmology Case Reports
Purpose: This report describes a case of Descemet membrane endothelial keratoplasty (DMEK) graft failure after non-clearing bullae over the area of the orientation mark on the graft. Methods: Case report. Results: The summary of the clinical presentation
Rawan Abdulaziz Alosaimy, Halah Bin Helayel, Muhammad Ali Ahad   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Immediate Sequential Bilateral Cataract Surgery: Are We Overstating the Case? [Response to Letter]

Clinical Ophthalmology
Samar Al-Swailem,1 Khabir Ahmad,2 Abdulaziz Jabr AlJbreen,3 Sara AlHilali1 1Anterior Segment Division, King Khaled Eye Specialist Hospital and Research Center, Riyadh, Saudi Arabia; 2Research Department, King Khaled Eye Specialist Hospital and Research ...
Al-Swailem S, Ahmad K, AlJbreen AJ, AlHilali S   +3 more
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source