Results 21 to 30 of about 41,351 (280)

Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]

Veterinarski Glasnik, 2010
Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M., Ivanović Saša R., Trailović-Nedeljković Jelena, Robertson Alan P.   +3 more
doaj   +1 more source

The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs

Immune Network, 2020
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival.
D. Son, Eun-Sook Lee, S. Adunyah
semanticscholar   +1 more source

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

Biomolecules, 2020
Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes, control of infections currently relies mainly on chemotherapy, but resistance is an increasing problem.
Maoxuan Liu, Sujogya Kumar Panda, W. Luyten   +2 more
semanticscholar   +1 more source

Cell Death and Transcriptional Responses Induced in Larvae of the Nematode Haemonchus contortus by Toxins/Toxicants with Broad Phylogenetic Efficacy

Pharmaceuticals, 2021
Establishing methods to investigate treatments that induce cell death in parasitic nematodes will promote experimental approaches to elucidate mechanisms and to identify prospective anthelmintics capable of inducing this outcome. Here, we extended recent
Douglas P. Jasmer, Bruce A. Rosa, Makedonka Mitreva   +2 more
doaj   +1 more source

Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease

Journal of Biomolecular Structure and Dynamics, 2020
SARS-CoV-2 or Coronavirus disease 19 (COVID-19) is a rapidly spreading, highly contagious, and sometimes fatal disease for which drug discovery and vaccine development are critical.
Mahmoud Kandeel, Alaa H. M. Abdelrahman, K. Oh‐hashi, A. Ibrahim, Katharigatta N. Venugopala, M. Morsy, Mahmoud A. A. Ibrahim   +6 more
semanticscholar   +1 more source

Anthelmintic resistance in gastrointestinal nematodes of alpacas (Vicugna pacos) in Australia

Parasites & Vectors, 2018
Background Gastrointestinal nematodes (GINs) can cause significant economic losses in alpacas due to lowered production of fibre and meat. Although no anthelmintics are registered for use in alpacas, various classes of anthelmintics are frequently used ...
Mohammed H. Rashid, Jane L. Vaughan, Mark A. Stevenson, Angus J. D. Campbell, Ian Beveridge, Abdul Jabbar   +5 more
doaj   +1 more source

A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity

Pharmaceuticals, 2022
Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus, are particularly important.
Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Abdul Jabbar, Tim N. C. Wells, Kirandeep Samby, Peter R. Boag, Nghi Nguyen, Brad E. Sleebs, Robin B. Gasser   +9 more
doaj   +1 more source

Simultaneous Determination of Multiple Contaminants in Chicken Liver Using Dispersive Liquid-Liquid Microextraction (DLLME) Detected by LC-HRMS/MS

Foods, 2023
Simultaneous determination of a mixture of food contaminants, including pesticides, sulphonamides, fluoroquinolones, anthelmintics, and aflatoxin B1, in solid biological samples (chicken liver) by dispersive liquid-liquid microextraction/liquid ...
Belete Eshetu Gebreyohannes, Simiso Dube, Mathew Muzi Nindi   +2 more
doaj   +1 more source

UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus

Frontiers in Physiology, 2020
The nematode Haemonchus contortus, a gastrointestinal parasite of ruminants, can severely burden livestock production. Although anthelmintics are the mainstay in the treatment of haemonchosis, their efficacy diminishes due to drug-resistance development ...
Pavlína Kellerová, Martina Navrátilová, Linh Thuy Nguyen, Diana Dimunová, Lucie Raisová Stuchlíková, Karolína Štěrbová, Lenka Skálová, Petra Matoušková   +7 more
doaj   +1 more source

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Veterinary Research, 2020
The efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes (DMEs), e.g.
Pavlína Kellerová, Lucie Raisová Stuchlíková, Petra Matoušková, Karolína Štěrbová, Jiří Lamka, Martina Navrátilová, Ivan Vokřál, Barbora Szotáková, Lenka Skálová   +8 more
doaj   +1 more source