Results 111 to 120 of about 6,366 (244)

Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: A Systematic Review and Meta-Analysis

, 2016
International audiencePurposePatients with metabolic syndrome have a greater risk of cardiovascular disease, although their susceptibility to chemotherapy-induced cardiac disease is not well documented.
Yu, Anthony, F, Yu, Anthony, F., Ladoire, Sylvain, Charles Guenancia, Cottin, Yves, François Ghiringhelli, Luc Rochette, Rochette, Luc, Yves Cottin, Lefebvre, Annick, Vergely, Catherine, Anthony F. Yu, Annick Lefebvre, Sylvain Ladoire, Marianne Zeller, Catherine Vergely, Daniela Cardinale, Zeller, Marianne, Guenancia, Charles, Cardinale, Daniela, Ghiringhelli, François   +20 more
core   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long‐Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab‐Based Chemotherapy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Long‐term survivors of breast cancer (BC) treated with doxorubicin and trastuzumab‐based chemotherapy are at increased risk of developing cardiovascular disease.
João E. Izaias, Artur O. Sales, Bruna E. Ono, Thais S. Rodrigues, Gabrielly M. P. S. Silva, Priscilla S. Pentagna, Andre L. P. Albuquerque, Flavia N. Folchini, Fernanda M. C. Colombo, Maria C. C. Irigoyen, Amanda G. Rodrigues, Carlos E. Negrão, Laura Testa, Natália G. Rocha, Helena N. M. Rocha, Gabriel F. Texeira, Antonio C. L. D. Nóbrega, Natália A. S. Miyaguti, Alex A. R. Silva, Andreia M. Porcari, Antonio Viana Nascimento‐Filho, Katia De Angelis, Daniel H. Craighead, Zachary S. Clayton, Katelyn R. Ludwig, Matthew J. Rossman, Douglas R. Seals, Renata Moll‐Bernardes, Allan R. K. Sales   +28 more
doaj   +1 more source

Eccrine Squamous Syringometaplasia Mimicking Acute Cutaneous GVHD in a Pediatric HSCT Recipient: Case Report and Brief Review of the Indexed Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Eccrine squamous syringometaplasia (ESS) is an uncommon reactive alteration of eccrine ducts, most often reported in oncologic and transplant settings, where it may clinically mimic acute cutaneous graft‐versus‐host disease (GVHD). We describe a 3‐year‐old boy with chronic granulomatous disease who developed a diffuse erythematous eruption 6 ...
Benedetta Galli, Cecilia Catapano, Iacopo Ghini, Mariateresa Rossi, Marina Venturini, Valeria Boccaletti   +5 more
wiley   +1 more source

The clinical trial landscape of osteosarcoma: integrating trial data, immunotherapeutic trends, and biomarker insights

Frontiers in Immunology
Osteosarcoma, the most aggressive primary malignant bone tumor, has stagnant therapeutic outcomes despite decades of standard MAP chemotherapy and surgery; 5-year overall survival (OS) is <30% for metastatic/recurrent cases.
Lifeng Ge, Tianhao Xu, Xiaodong Gu, Xuekang Pan, Tian Gao, Huigen Lu   +5 more
doaj   +1 more source

Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5

British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino, Edurne San José‐Enériz, Leire Garate, Estibaliz Miranda, Elena Sáez, Antonio Pineda‐Lucena, Felipe Prósper, Xabier Agirre   +7 more
wiley   +1 more source

Survival After Diagnosis of Cardiovascular Disease in Survivors of Adolescent and Young Adult Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Cardiac dysfunction is a major morbidity among survivors of adolescent and young adult (AYA) lymphoma. Although high mortality after cardiovascular disease (CVD) diagnosis has been shown in other cancer survivor populations, this has not been investigated in a diverse population of survivors of AYA lymphoma.
Karan Gowda, Medha Gupta, Adrian Aguilar, Carlos Cruz, Amanda Warner, Elizabeth R. Rodriguez, Sairah Ahmed, Branko Cuglievan, Joel Milam, David R. Freyer, Kimberly A. Miller, Greg Aune, Debra Eshelman‐Kent, Karen Albritton, Efstratios Koutroumpakis, Michael E. Roth, Jian Wang, Michelle A. T. Hildebrandt   +17 more
wiley   +1 more source

Efficacy and safety of liposomal anthracyclines in Phase I/II clinical trials

, 2004
Preclinical studies have established the pharmacologic advantages of liposomal anthracyclines, including pharmacokinetic profiles after bolus dosing that resemble continuous infusion of conventional anthracyclines, increased drug concentrations in tumor ...
Dibella, Nicholas J, Sparano, Joseph A, Jahanzeb, Mohammad, Rivera, Edgardo, Venook, Alan P, Stewart, Simon J, Gabizon, Alberto A, Muggia, Franco M, Carmichael, James, Alberts, David S, Kavanagh, John J, Winer, Eric P, Skubitz, Keith M   +12 more
core   +1 more source

Is universal CAR T‐cell referral absolutely required for transplant‐ineligible patients with primary refractory or early relapsed DLBCL?

British Journal of Haematology, EarlyView.
Maria Dimou, Theodoros P. Vassilakopoulos   +1 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source