Results 131 to 140 of about 6,366 (244)

Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin

The Journal of Physiology, EarlyView.
Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George, Amber V. Mills, Erin O'Neill, Sofian N. Obaid, Igor R. Efimov, Tatiana Efimova   +5 more
wiley   +1 more source

DNA unwinding and inhibition of T4 DNA ligase by anthracyclines

, 1988
The ability to alter DNA tertiary structure of ten anthracycline derivatives whose antitumor potency is known was studied by an assay that makes use of nicked circular DNA and bacteriophage T4 DNA ligase.
MONTECUCCO A., CIARROCCHI G., PEDRALI NOY G., SPADARI S., ZANOLIN, Maria Elisabetta   +4 more
core  

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, Volume 159, Issue 2, Page 460-466, 15 July 2026.
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Completion vs. early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2272-2283, July 2026.
Abstract Aim Chemotherapy is given for early‐stage breast cancer; however, some patients discontinue before completing all planned cycles. This study investigated the impact of early chemotherapy discontinuation on treatment outcomes. Methods This retrospective cohort study used a target trial emulation framework to conduct a causal analysis of the all‐
Luke Steventon, Chengsheng Ju, Kenneth K. C. Man, Rebecca Roylance, Diego Ottaviani, Chiara Creed, Michal Sladkowski, Alec Wisner, Li Wei, Pinkie Chambers   +9 more
wiley   +1 more source

Anthracyclines and the heart [PDF]

Heart, 1994
openaire   +2 more sources

Medroxyprogesterone acetate increases anthracyclines uptake in chronic lymphatic cells: Role of nitric oxide and lipid peroxidation

, 2000
Anthracyclines are one of the most used drugs in the therapy of several malignant tumors. Unfortunately its use is still limited by their cardio-toxicity and by the presence of cancer cells resistant to these drugs.
CRISPINO A., PAGNINI G., PACILIO C., GIORDANO A., PAGNINI U., FLORIO S., CLAUDIO P. P.   +6 more
core  

Combination Therapy With Sintilimab and Anlotinib for Advanced Undifferentiated Pleomorphic Sarcoma: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT This report describes the case of a 73‐year‐old woman with advanced undifferentiated pleomorphic sarcoma (UPS) who was intolerant to chemotherapy. Following amputation, she received sintilimab plus anlotinib and achieved a partial response with 76.6% tumor reduction.
Yan Chen, Ronghua Chu
wiley   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

, 2009
The optimization, validation and application of a liquid chromatographic method with fluorescence detection for the simultaneous determination of the four most important anthracyclines (doxorubicin, epirubicin, daunorubicin and idarubicin) and their ...
Maudens, Kristof
core  

The Effect of Strength Training During Chemotherapy in Women With Breast Cancer on Serum Cytokine Concentrations and Skeletal Muscle Autophagy‐Related Proteins

European Journal of Sport Science, Volume 26, Issue 7, July 2026.
ABSTRACT To evaluate whether strength training during chemotherapy alters (1) serum cytokines and (2) skeletal muscle autophagy‐ and heat‐shock‐related proteins in women with breast cancer. Exploratory analyses assessed associations between changes in physiological outcomes (muscle strength, cardiorespiratory fitness, and capillary density) and ...
Emelie Strandberg, Olav Vikmoen, Karianne Vassbakk Svindland, Atle Wendel Scheie, Hege Nymo Ødemark, Anna Henriksson, Sveinung Berntsen, Truls Raastad   +7 more
wiley   +1 more source