Results 151 to 160 of about 6,366 (244)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Theoretical ground for adsorptive therapy of anthracyclines cardiotoxicity

, 2012
Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity.
Nikolaev, V.G., Posokhova, E.A., Shevchuk, O.O., Sakhno, L.A.   +3 more
core  

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

A Doxorubicin‐Loaded Liposomes Baghdadite System for Localized Osteosarcoma Therapy and Bone Regeneration

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
This study presents a multifunctional Baghdadite ceramic implant integrating doxorubicin‐loaded liposomes via ion‐assisted plasma polymer coating for localized osteosarcoma therapy. The platform enables drug retention, sustained release, tumor cell inhibition, osteoconductivity, and antibacterial activity, offering a mechanically robust strategy for ...
Sally Kortam, Zufu Lu, Iman Roohani, Ghazal Shineh, Leila Mamizadeh Janghour, Huu Nguyen Ngoc, Pooria Lesani, Behnam Akhavan, Hala Zreiqat   +8 more
wiley   +1 more source

Expert Consensus on the Clinical Application of Poly ADP Ribose Polymerase Inhibitors in Breast Cancer (2025 Edition)

Cancer Innovation, Volume 5, Issue 3, June 2026.
This consensus, based on the latest evidence‐based medical data, provides guidance on the standardized application and safety management of PARP inhibitors in breast cancer treatment, aiming to serve as a reference for clinical practice. ABSTRACT Breast cancer represents a major threat to women's health in China.
Fei Ma, Binghe Xu, China Anti‐Cancer Association Committee on Clinical Research of Anticancer Drugs, National Expert Committee on Monitoring Clinical Application of Antineoplastic Drugs, Breast Cancer Expert Committee of National Cancer Quality Control Center, Expert Committee on Chemotherapy Quality Control of Beijing Cancer Treatment Quality Control and Improvement Center   +5 more
wiley   +1 more source

Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 3, June 2026.
Immunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Katherine Yaacoub
wiley   +1 more source

Metastatic Ewing Sarcoma, Patterns of Care and Outcomes of Patients in a Real‐Life National Setting Over a Decade

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Metastatic Ewing sarcoma (MES) has a poor prognosis. This multicenter observational study provides real‐world data on treatment patterns of patients with MES in France. Treatment characteristics, outcomes such as time to next treatment (TTNT) and overall survival (OS), and prognostic factors of patients aged ≥ 12 years treated for a MES in 11 ...
Coline Ducrot, Derek Dinart, Maeva Bonneau, Max Piffoux, Marie Sophie Minot, Juliane Mignot‐Posson, Thomas Grinda, Jordane Chaix, Sarah Winter, Pauline Gerard, Romain Duong, Berengère Narciso, Natacha Entze Werle, Cécile Vérité, Valérie Laurence, Axel Le Cesne, Pablo Berlanga, Camille Tlemsani, Pascaline Boudou‐Rouquette, Emmanuelle Bompas, Thibaud Valentin, Nadège Corradini, Mehdi Brahmi, Carine Bellera, Maud Toulmonde   +24 more
wiley   +1 more source

Characteristics and Outcomes of Patients With Dedifferentiated Liposarcoma in a US Community Setting

Cancer Medicine, Volume 15, Issue 6, June 2026.
US community oncology patients with dedifferentiated liposarcoma have heterogeneous profiles, treatments, and outcomes. The poor survival rates in this population suggest an unmet need for better therapeutics. ABSTRACT Introduction Clinical characteristics and outcomes of patients treated for dedifferentiated liposarcoma (DDLPS) at community oncology ...
James E. Butrynski, Bal Nepal, Chenxiao Hu, Jinhong Guo, Jennifer Han, Lisa Herms, Alyssa B. Klein, Stephen Stanhope, Elizabeth L. Stanley, Karen Todoroff, Paul Conkling   +10 more
wiley   +1 more source

Primary Cardiac Angiosarcoma in a Young Male: Rare Presentation With Right Atrial Endocardial Dissection and Right Coronary Artery Tumor Fistula

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT We report the case of a 19‐year‐old man who presented with several months of exertional dyspnea and recent‐onset hemostasis. Initial imaging revealed multiple pulmonary nodules. Days later, he was referred to a specialized center with chest pain and signs of pericarditis.
Nehzat Akiash, Ramtin Rezaee Kalantari, Somayeh Abbaspour, Mahlasadat Masoumi, Narges Eslami, Nasibeh Akiash, Mahboubeh Pazoki, Shahab Rajabzadeh, Soroush Mostafavi   +8 more
wiley   +1 more source