Results 161 to 170 of about 47,221 (287)

Treatment of left ventricular dysfunction during cancer therapy: a comprehensive review. [PDF]

Drugs Context
Kaplinsky E, Barbagelata A, Giorgi J, Fischer-Bacca CO.   +3 more
europepmc   +1 more source

Triple‐Negative Breast Cancer Versus Non‐Triple‐Negative Breast Cancer: The Impact of Pd and Pt Complexes on Basal‐Like Triple‐Negative Breast Cancer

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
The anticancer activity of the complexes Pd3Spd2, Pt3Spd2, Pt2Put2(NH3)4 and Pd2Put2 against human TNBC, non‐TNBC and healthy breast cells was evaluated. The metabolic impact of the most promising metal complexes—Pd3Spd2 and Pt2Put2(NH3)4—was further assessed using vibrational microspectroscopies, providing detailed insights into the drug‐induced ...
Clara B. Martins, Maria P. M. Marques, Luís A. E. Batista de Carvalho, Ana L. M. Batista de Carvalho   +3 more
wiley   +1 more source

Cardiac digital twins: Modelling the arrhythmic substrate of chemotherapy

The Journal of Physiology, EarlyView.
Radomir Chabiniok, Vlad G. Zaha
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Intensive Chemotherapy With or Without Midostaurin in Adults ≥ 60 Years Old With FLT3‐Mutated AML: A FILO‐DATAML‐PETHEMA Real‐World Study

American Journal of Hematology, Volume 101, Issue 5, Page 949-960, May 2026.
ABSTRACT The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with FLT3‐mutated acute myeloid leukemia (AML); however, real‐world data in elderly patients (≥ 60 years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (n ...
Gaspar Aspas Requena, Pau Montesinos, Emilie Bérard, Sarah Bertoli, Rebeca Rodríguez‐Veiga, Celestine Simand, Laura Torres, Pierre Peterlin, Mar Tormo, Rudy Birsen, Juan Miguel Bergua‐Burgues, Emmanuelle Tavernier, Teresa Bernal del Castillo, Martin Carré, Cristina Gil, Adrien Contejean, Eduardo Rodríguez‐Arbolí, Corentin Orvain, Carlos Rodríguez‐Medina, Lauren Veronese, Maria Jose Sayas Lloris, Eric Delabesse, Josefina Serrano, Ariane Mineur, María García‐Fortes, Romain Guieze, Maria Luz Amigo, Arnaud Pigneux, Lorenzo Algarra Algarra, Christian Recher, Pierre‐Yves Dumas, David Martínez‐Cuadrón   +31 more
wiley   +1 more source

Early detection of cardiotoxicity in pediatric and adolescent patients with cancer treated with anthracyclines in Northeastern Brazil. [PDF]

Hematol Transfus Cell Ther
Martins JL, Aragão Magalhães Feitosa FG, Câmara Dos Santos MV, Leão de Menezes TMGA, Sena AD, Rodrigues EPL, Lopes MBA, Laís Dos Santos J, Duarte MDCMB.   +8 more
europepmc   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1457-1472, May 2026.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Cardiotoxicity of Antitumor Agents: Therapeutic Challenges in Heart Failure with Reduced and Preserved Ejection Fraction. [PDF]

Int J Mol Sci
Tana M, Piccinini R, Pinterpe G, Porreca E, Berardi R, Tana C.   +5 more
europepmc   +1 more source

GATA2 Mutations Predict Poor Prognosis in Transplanted Myeloid Neoplasms

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background GATA binding protein 2 (GATA2) plays a crucial role in the differentiation, proliferation, and maintenance of hematopoietic stem cells (HSCs). GATA2 mutations have been identified in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), but the impact of somatic GATA2 mutations on prognosis remains controversial ...
Xian Zhang, Bingjie Wang, Yujun Dong, Qingya Wang, Qian Wang, Jialin Zhu, Qingyun Wang, Na Han, Yuan Li   +8 more
wiley   +1 more source

Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients. [PDF]

JACC Basic Transl Sci
Hsu PY, Huang WH, Lee YY, Passier R, Li SC, Hong CL, Hung SK, Lin HY, Lin CH, Chien CY, Li YD, Lee HC, Désaubry L, Nebigil CG, Chan MWY.   +14 more
europepmc   +1 more source