Results 161 to 170 of about 6,366 (244)

Beyond the Triple‐Negative Label: A Case Report on Metaplastic Breast Carcinoma

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Metaplastic breast carcinoma (MpBC) is a rare, aggressive breast malignancy with poorer prognosis than conventional subtypes. Predominant hematogenous spread, frequent triple‐negative phenotype, chemoresistance, rarity, and poorly defined treatment protocols render MpBC a significant diagnostic and therapeutic challenge for oncologists in ...
Samana Oli, Ayush Sapkota, Sajjad Ahmed Khan, Asmita Rayamajhi, Dhiraj Gupta, Vivek Ghosh, Diksha Karki, Rikesh Acharya, Prajina Shrestha   +8 more
wiley   +1 more source

Primary Extramedullary Acute Promyelocytic Leukemia Presenting as Cauda Equina Syndrome: A Rare Case Report and Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT APL presenting as an extramedullary mass is exceedingly rare. Here, we describe extramedullary APL causing cauda equina syndrome, underscoring the diagnostic challenges associated with an atypical presentation, highlighting the complexity of distinguishing extramedullary APL from other conditions, and discussing the stepwise approach to ...
Amir Ali, Marc Ringor, Arbab Khalid, Diana Garcia, Ravishankar Konchada, Ramalingam Ratnasabapathy, Yuna Chae, Arman Melikyan, George Yaghmour   +8 more
wiley   +1 more source

From Leukemia to Solid Tumors, Successful Multidisciplinary Management of Three Distinct Primary Cancers in a Single Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT A 41‐year‐old man developed three distinct primary malignancies—acute myeloid leukemia, male breast cancer, and metastatic colorectal cancer—within 7 years. This rare case highlights the evolving challenge of multiple primary cancers and demonstrates how coordinated multidisciplinary care can preserve curative intent despite successive life ...
Abolfazl Khalafi‐Nezhad, Nazanin Alemzadeh, Mohammad Hossein Anbardar, Zahra Ghanbarinasab   +3 more
wiley   +1 more source

Cytokine receptor and JAK/STAT pathway mutations in acute myeloid leukemia: Prevalence and clinical impact

Cancer, Volume 132, Issue 11, 1 June 2026.
Abstract Background Mutations in cytokine receptor and JAK/STAT; Cy‐JAK/STAT) signaling genes drive myeloproliferative neoplasms (MPNs) but remain incompletely characterized in acute myeloid leukemia (AML). The authors evaluated the prevalence, clinical presentation, and prognostic significance of Cy‐JAK/STAT pathway mutations in patients with AML and ...
Moath Albliwi, Daniel P. Nurse, Emily C. Zabor, John Hanna, Jessica El‐Asmar, Ameed Bawwab, Hasan Abuamsha, Yomna Abu‐Farsakh, Heya Batah, Asad Rauf, Joy Nakitandwe, David S. Bosler, Prerana Bangalore Parthasarathy, Tyler Alban, Akriti G. Jain, John C. Molina, Sophia Balderman, Abhay Singh, Aaron T. Gerds, Sudipto Mukherjee, Anjali S. Advani, Hetty E. Carraway, Moaath K. Mustafa Ali   +22 more
wiley   +1 more source

Impact of Frontline Treatment Strategies on Outcomes in Patients With Acute Myeloid Leukemia, Myelodysplasia‐Related

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background The 5th edition of the World Health Organization (WHO) classification updated the term for acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) to acute myeloid leukemia, myelodysplasia‐related (AML‐MR), along with new diagnostic criteria.
Yi Li, Dian Jin, Peiying Fang, Xinyi meng, Donghua He, Jintao Lin, Jing Le, Wenxiu Shu, Qianqian Yang, Jingsong He, Zhen Cai   +10 more
wiley   +1 more source

Case Series: Can Daily Patient‐Reported Outcome Measures Be Implemented for Cancer‐Related Fatigue?

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Cancer‐related fatigue (CrF), a prevalent and debilitating symptom among cancer patients, remains underrecognized and unstandardized in routine oncology care. To address this, we introduced a new digital tool for daily CrF measurement and integration in routine cancer treatment.
Alexander Tilg, Andreas Meryk, Johannes G. Weiss, Roman Crazzolara   +3 more
wiley   +1 more source

Assessment of Doxorubicin Internalization and Cytotoxicity in Primary Tumor Spheroids After Collagen Digestion

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract The limited penetration of chemotherapeutic agents into solid tumors remains a major obstacle to effective cancer treatment and is strongly influenced by the extracellular matrix (ECM). Three‐dimensional (3D) tumor spheroids derived from primary tumor cells (PTCs) represent a valuable in vitro model to study how ECM composition and ...
Alessandra Lo Cicero, Gabriele Lo Buglio, Simona Campora, Giulio Ghersi   +3 more
wiley   +1 more source

Folate receptor beta targeting of tumor‐associated macrophages improves lymphoma cell responses to CD19 CAR T cells

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of patients with relapsed or refractory (R/R) diffuse large B‐cell lymphoma (DLBCL). However, approximately half of the patients experience lymphoma progression after CD19 CAR T cell therapy.
Kerttu Kalander, Katri Oksa, Selma Sorri, Hector Monzo, Suvi‐Katri Leivonen, Päivi M. Ojala, Sirpa Leppä   +6 more
wiley   +1 more source

Peripheral T‐Cell Lymphomas in Southern Taiwan: Epidemiology, Treatment Patterns, and Long‐Term Outcomes

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Peripheral T‐cell lymphomas (PTCLs) are heterogeneous neoplasms with poor prognosis and marked geographic variation. Data from Taiwan remain limited. We conducted a 15‐year retrospective cohort study of 249 patients diagnosed with PTCL at two major centers in southern Taiwan between 2010 and 2024 to characterize regional epidemiology, real ...
Bo‐Yu Huang, Li‐Chang Chang, Sheng‐Yen Hsiao, Ya‐Ping Chen, Sin‐Syue Li, Pei‐An Fu, Chen Chang, Kung‐Chao Chang, Tsai‐Yun Chen, Ya‐Ting Hsu   +9 more
wiley   +1 more source

T‐Cell Acute Lymphoblastic Leukemia in a Young Patient With Andersen–Tawil Syndrome Successfully and Safely Treated With Intensive Chemotherapy Including Potential Precipitating Drugs: A Case Report After 3.5 Years of Follow‐up

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Andersen–Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27‐year‐old man with genetically confirmed Type 1 ATS who developed T‐cell acute ...
Ramy Rahmé, Paule Moussounda Bamba, Thi Thuy Duong Do, Anthony Behin, Estelle Gandjbakhch, Claude Gardin, Thorsten Braun   +6 more
wiley   +1 more source