Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers. [PDF]
Panovský R +11 more
europepmc +1 more source
ABSTRACT The randomized, multicenter, prospective Phase 3 trial (NCT02777736) evaluated central nervous system (CNS) prophylaxis using either intravenous (i.v.) or intrathecal (i.t.) methotrexate (MTX) in diffuse large B‐cell lymphoma (DLBCL). Treatment consisted of six cycles of R‐CHOP + 2xR or DA‐EPOCH‐R + 2xR. Patients with intermediate or high‐risk
H. Mocikova +12 more
wiley +1 more source
Protecting the Heart Against Anthracyclines: The Elusive Search for the Optimal Cardiomyocyte Model. [PDF]
Narvaez-Paliza JM, Asnani A.
europepmc +1 more source
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
The trajectory of fatigue over time in breast cancer patients treated with chemotherapy: exploring the effect of anthracycline-based chemotherapy. [PDF]
Kastelein A +10 more
europepmc +1 more source
ABSTRACT Introduction Pathological complete response (pCR) after neoadjuvant chemotherapy is associated with improved prognosis in patients with triple‐negative breast cancer (TNBC). Differences in pathological response rates between the breast and axillary lymph nodes have prompted interest in understanding response patterns that may, in the future ...
Milena Martello Cristófalo +7 more
wiley +1 more source
Association of early dexrazoxane with reduced cardiotoxicity risk in sarcoma patients treated with anthracycline chemotherapy. [PDF]
Jang KH +6 more
europepmc +1 more source
MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen +4 more
wiley +1 more source
Caught in the crossfire: cardiac complications of cancer therapy. [PDF]
Guerra G +4 more
europepmc +1 more source

