Results 191 to 200 of about 47,221 (287)

TGFβ‐Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia

Molecular Carcinogenesis, Volume 65, Issue 5, Page 556-564, May 2026.
ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Akash Maity, Rohit Kumar, Madhavi Dutta, Ansit Mishra, Jitendra Gawde, Jagruti Patil, Darshana Kadam, Sumeet Mirgh, Anant Gokarn, Hasmukh Jain, Lingaraj Nayak, Bhausaheb Bagal, Sachin Punatar, Manju Sengar, Navin Khattry, P. G. Subramanian, Prashant Tembhare, Syed K. Hasan   +17 more
wiley   +1 more source

Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study. [PDF]

Eur Heart J
Aba N, Le Teuff G, Fresneau B, Koscielny S, Belhechmi S, Schwartz B, El-Fayech C, Rubino C, Allodji RS, Morel E, Dayde D, de la Grange P, Jolly A, Pata-Merci N, Cordero C, Aerts I, Pein F, Vu-Bezin G, De Vathaire F, Haddy N.   +19 more
europepmc   +1 more source

Left ventricular fibrosarcoma in a 4‐year‐old labrador

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 4‐year‐old, male, neutered labrador presented for investigations into a single episode of collapse and an intracardiac mass. Echocardiography and computed tomography confirmed the presence of a large soft tissue mass within the left ventricular lumen, which nearly obstructed the left ventricular outflow tract.
Natalia Caldecott, Radu Constantinescu, Catherine Ennett, Tsumugi Anne Kurosawa, David Brewer   +4 more
wiley   +1 more source

Pediatric Cardio-Oncology: From Gap in Evidence to Future Perspectives. [PDF]

Diagnostics (Basel)
Correra A, Cetoretta V, Maratea AC, Ferrara S, Di Sarno I, Russo V, Guerra F, Mauriello A, D'Andrea A.   +8 more
europepmc   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, Volume 117, Issue 5, Page 1273-1285, May 2026.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Correction for Abels et al., Manipulating anthracyclines for deeper tissue penetration and implications for glycolytic tissues. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

CT-derived myosteatosis for baseline risk stratification of cardiotoxicity in patients with diffuse large B-cell lymphoma receiving anthracyclines. [PDF]

BMC Med Imaging
Shen H, Tu C, Xie Y, Xu Q, Deng Y, Zhang J, Guo D.   +6 more
europepmc   +1 more source

Frontline Therapy in Diffuse Large B‐Cell Lymphoma: Evolving Standards, Biological Insights, and Future Directions

European Journal of Haematology, Volume 116, Issue 5, Page 522-534, May 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) remains the most common aggressive lymphoma, representing a biologically heterogeneous disease with diverse clinical behaviors. For more than two decades, R‐CHOP has been the cornerstone of frontline treatment, curing approximately two‐thirds of patients.
Mamdouh Skafi, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Fortunato Morabito, Enrica Antonia Martino, Massimo Gentile   +12 more
wiley   +1 more source

First-line Anlotinib plus Anthracyclines and Ifosfamide Followed by Anlotinib Maintenance in Advanced Soft-Tissue Sarcoma: A Phase II Single-Arm Trial. [PDF]

Clin Cancer Res
Zhao JK, Liu ZJ, Wang R, Fu H, Liu MY, Xu J, Xu X, Fan XC, Hu WY, Zhang H, Xu N, Hao T, Yuan HT, Zhang JB, Li MH, Zhou L, Yang CS, Wang XY, Zhu DY.   +18 more
europepmc   +1 more source

Regulation of Endoplasmic Reticulum Stress by Empagliflozin in Doxorubicin‐Induced Cardiotoxicity in Rats

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Although Doxorubicin (Dox) is an effective anticancer drug, it can cause severe cardiotoxicity. While several mechanisms have been proposed to explain Dox‐induced cardiomyopathy (DIC), strategies to prevent it remain limited. In previous research on isolated cardiomyocytes, we identified that Empagliflozin (EMPA), an antidiabetic drug ...
Akshi Malik, David C. Y. Cheung, D. Allison Ledingham, Danielle Desautels, Joerg Herrmann, Pawan K. Singal, Davinder S. Jassal   +6 more
wiley   +1 more source