Results 21 to 30 of about 10,626 (204)

Anthraquinones as Inhibitors of SOS RAS-GEF Activity

open access: yesBiomolecules, 2021
Recent breakthroughs have reignited interest in RAS GEFs as direct therapeutic targets. To search for new inhibitors of SOS GEF activity, a repository of known/approved compounds (NIH-NACTS) and a library of new marine compounds (Biomar Microbial ...
Alberto Fernández-Medarde   +6 more
doaj   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

open access: yesAngewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao   +8 more
wiley   +2 more sources

Constituintes químicos do caule de Senna reticulata Willd. (Leguminoseae): Chemical constituents isolated from the wood of Senna reticulata Willd.

open access: yesQuímica Nova, 2008
The phytochemical investigation of the wood extracts of Senna reticulata (Leguminoseae) yielded six anthraquinones: chrysophanol, physcion, aloe-emodin, 1,3,8-trihydroxyanthraquinone, 3-methoxy-1,6,8-trihydroxyanthraquinone, emodin and the chrysophanol ...
Rogério Nunes dos Santos   +2 more
doaj   +1 more source

Role of anthraquinones in combating insulin resistance

open access: yesFrontiers in Pharmacology, 2023
Insulin resistance presents a formidable public health challenge that is intricately linked to the onset and progression of various chronic ailments, including diabetes, cardiovascular disease, hypertension, metabolic syndrome, nonalcoholic fatty liver ...
Wanru Xia   +8 more
doaj   +1 more source

Boosting Charge Storage in Ferri/Ferrocyanide‐Based Alkaline Redox Flow Batteries

open access: yesAngewandte Chemie, EarlyView.
By modifying the solvation environment, cation engineering through Li+ substitution of traditional K+ or Na+ boosts the alkaline solubility of the ferri/ferrocyanide catholyte redox couple, providing a viable pathway to overcome the long‐standing challenge of energy density limitations for aqueous redox flow batteries (RBFs).
Mahla Sarfaraz Khabbaz   +6 more
wiley   +2 more sources

Chemical Diversity and Biological Activities of Phaeosphaeria Fungi Genus: A Systematic Review

open access: yesJournal of Fungi, 2018
Microbial natural products (MNPs) have been identified as important hotspots and effective sources for drug lead discovery. The genus Phaeosphaeria (family: Phaeosphaeriaceae, order: Pleosporales), in particular, has produced divergent chemical ...
Amr El-Demerdash
doaj   +1 more source

HPTLC-DESI-HRMS-Based Profiling of Anthraquinones in Complex Mixtures—A Proof-of-Concept Study Using Crude Extracts of Chilean Mushrooms

open access: yesFoods, 2020
High-performance thin-layer chromatography (HPTLC) coupled with negative ion desorption electrospray ionization high-resolution mass spectrometry (DESI-HRMS) was used for the analysis of anthraquinones in complex crude extracts of Chilean dermocyboid ...
Annegret Laub   +5 more
doaj   +1 more source

Increased Free Radical Generation during the Interaction of a Quinone-Quinoline Chelator with Metal Ions and the Enhancing Effect of Light

open access: yesPharmaceuticals, 2023
Schiff bases and similar molecules forming metal complexes may cause redox effects, which may also be influenced by light. Anthraquinones such as doxorubicin and idarubicin are widely used antitumor agents, which can generate reactive oxygen species (ROS)
Olga Yu. Selyutina   +4 more
doaj   +1 more source

Defect‐Rich CoNi Prussian Blue Analogues Enable Highly Selective Electrochemical Hydrogen Peroxide Production

open access: yesAngewandte Chemie, EarlyView.
Introducing [Co(CN)6]3− defects into CoNi Prussian Blue analogues exposes square‐planar Ni–N4 active sites, leading to remarkable H2O2 selectivity during the electrochemical oxygen reduction reaction in alkaline media. ABSTRACT Decentralized electrosynthesis of hydrogen peroxide (H2O2) via the two‐electron oxygen reduction reaction (2e− ORR) offers a ...
Kai Sun   +4 more
wiley   +2 more sources

Phytochemistry, Ethnopharmacological Uses, Biological Activities, and Therapeutic Applications of Cassia obtusifolia L.: A Comprehensive Review

open access: yesMolecules, 2021
Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, and natural remedy for treating headache, dizziness, constipation, tophobia, and lacrimation and for improving eyesight.
Md Yousof Ali   +2 more
doaj   +1 more source

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