Binding Stoichiometry and Kinetics of the Interaction of a Human Anthrax Toxin Receptor, CMG2, with Protective Antigen [PDF]
Darran J. Wigelsworth+5 more
openalex +1 more source
Transformer-based toxin-protein interaction analysis prioritizes airborne particulate matter components with potential adverse health effects [PDF]
Air pollution, particularly airborne particulate matter (PM), poses a significant threat to public health globally. It is crucial to comprehend the association between PM-associated toxic components and their cellular targets in humans to understand the mechanisms by which air pollution impacts health and to establish causal relationships between air ...
arxiv
BioTD: an online database of biotoxins [PDF]
Biotoxins, mainly produced by venomous animals, plants and microorganisms, exhibit high physiological activity and unique effects such as lowering blood pressure and analgesia. A number of venom-derived drugs are already available on the market, with many more candidates currently undergoing clinical and laboratory studies.
arxiv
Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery. [PDF]
Becker L, Verdurmen WPR, Plückthun A.
europepmc +1 more source
Can Large Language Models Design Biological Weapons? Evaluating Moremi Bio [PDF]
Advances in AI, particularly LLMs, have dramatically shortened drug discovery cycles by up to 40% and improved molecular target identification. However, these innovations also raise dual-use concerns by enabling the design of toxic compounds. Prompting Moremi Bio Agent without the safety guardrails to specifically design novel toxic substances, our ...
arxiv
Role of Toxin Functional Domains in Anthrax Pathogenesis
Fabien Brossier+3 more
openalex +1 more source
Protein Translocation through Anthrax Toxin Channels Formed in Planar Lipid Bilayers [PDF]
Sen Zhang+4 more
openalex +1 more source
Structural and Kinetic Analyses of the Interaction of Anthrax Adenylyl Cyclase Toxin with Reaction Products cAMP and Pyrophosphate [PDF]
Qing Guo+4 more
openalex +1 more source