Results 121 to 130 of about 12,264,289 (383)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

FDA Regulation and the New Anti-aging Products [PDF]

, 2012
In the decades since the enactment of the Federal Food, Drug, and Cosmetic Act (the "Act")' in 1938, one of the more persistent challenges facing the Food and Drug Administration (the "FDA") has been to apply an old statute to the regulatory problems ...
Hensel, Donald P.
core  

Consumers and Food Choice: Quality, Nutrition and Genes [PDF]

, 2010
The quantity and quality of food needed for reproduction differs from nutritional needs for health and longevity. The choice of food type and amount is driven by our genetic need for growth and reproduction, not for long term health.
Borut Poljsak, B., Iztok Ostan, I., Simcic, M., Tijskens, L.M.M.   +3 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Carotenoids - Effective Radical Scavengers for Healthy and Beautiful Skin [PDF]

, 2019
Free radicals are involved in various diseases and skin aging. To reduce and prevent this risk, our body produces antioxidants that can neutralize free radicals.
Darvin, Maxim E., Elpelt, Anja, Lademann, Jürgen, Lohan, Silke B., Meinke, Martina C.   +4 more
core   +1 more source

Cognitive skills improved by BrainWare SAFARI training program: Electroencephalographic study

Asian Journal of Medical Sciences, 2020
Background: Executive functions have been shown to be related to academic achievement and the ability to learn. Understanding the role of executive function may offer new learning opportunities for children.
Phakkharawat Sittiprapaporn
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Chitin and lignin. Natural ingredients from waste materials to make innovative and healthy products for humans and plant [PDF]

, 2017
In a globalized world, plants are continually cut to obtain free land for intensive farming without remembering their important function in the planet ecosystem.
Morganti, Pierfrancesco, Stoller, Marco
core   +1 more source

Enhancing Nuclei Segmentation in Histopathology Images via Quantitative to Qualitative Transitions in Supervised and Weakly Supervised Deep-Learning Approaches

IEEE Access
Segmentation of nuclei in histopathology images stained with Hematoxylin and Eosin is essential for accurate disease diagnosis and tissue characterization.
Ijaz Muhammad Umer, Haider Ali, Moon-Il Joo, Hee-Cheol Kim   +3 more
doaj   +1 more source