Results 101 to 110 of about 384,866 (306)

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis   +8 more
wiley   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Advances in plant essential oils and drug delivery systems for skincare

Frontiers in Pharmacology
BackgroundEssential oils, often referred to as “liquid gold,” are renowned for their broad biological activity. Ancient Egyptians used essential oils’ antibacterial and antiseptic effects to preserve mummies, ancient Greeks used olive oil for sun ...
Wang Yihan, Dou Jinjin, Dou Jinjin, Wang Yingqi, Mu Guanai, Zhang Xiwu   +5 more
doaj   +1 more source

In‐hospital outcomes of lacosamide versus levetiracetam for early adjunctive treatment of status epilepticus: A Nationwide Japanese retrospective cohort study

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a neurological emergency requiring immediate treatment. Although intravenous lacosamide (LCM) is used for the management of epilepsy, its effectiveness in treating SE remains unclear. We aimed to compare the in‐hospital outcomes between intravenous LCM and levetiracetam (LEV) as an early adjunctive therapy ...
Yumiko Nakamura, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Yuichiro Shirota, Masashi Hamada, Kiyohide Fushimi, Tatsushi Toda, Satoshi Kodama   +8 more
wiley   +1 more source

A real-world study on the clinicopathological profile, treatment outcomes and health-related quality of life, anxiety and depression among patients with desmoid tumor at two tertiary care centers in India

Frontiers in Oncology
BackgroundThe medical management of DT comprises tyrosine kinase inhibitors (TKIs), hormonal agents, anti-inflammatory drugs with the recently approved gamma secretase inhibitor nirogacestat being the current standard of care. Real-world data on evolving
Ghazal Tansir, Aparna Sharma, Bivas Biswas, Suryadev Narayan Sah, Somnath Roy, S. V. S. Deo, Sandeep Agarwala, Shah Alam Khan, Sameer Bakhshi, Deepam Pushpam   +9 more
doaj   +1 more source

Temporal Trends in the Epidemiology of Eating Disorders Between 2000 and 2022: A Danish Register Study of Their Incidence and Comorbidities

European Eating Disorders Review, EarlyView.
ABSTRACT Background Eating disorders are debilitating illnesses that often co‐occur with other psychiatric disorders and somatic diseases. Evidence indicates that the incidence of eating disorders has been increasing. We first examine the landscape of EDs over time, including the COVID‐19 period, via assessing the incidence of anorexia nervosa (AN ...
Nadia Micali, Helena L. Davies, Heidi Jeannet Graff, Laust H. Mortensen, Emilie R. Hegelund   +4 more
wiley   +1 more source

Pharmacological evaluation of novel 5-HT ₃ receptor antagonist, QCM-13 (N-cyclohexyl-3-methoxyquinoxalin-2-carboxamide) as anti-anxiety agent in behavioral test battery

, 2015
Deepali Gupta, Mahesh Radhakrishnan, Thangaraj Devadoss, Yeshwant Kurhe   +3 more
openalex   +1 more source

Age‐Related Trends in Eating‐Pathology Symptoms Among Sexual Minority Adults

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To examine how eating‐disorder symptoms vary by chronological age and sexual orientation in sexual minority adults. Method Cross‐sectional data came from 2062 cisgender sexual minority participants (925 gay men, 573 lesbian women, 116 bi+ men, 448 bi+ women; age = 47.8 years, range = 18–96).
Jason M. Nagata, Christopher D. Otmar, Char Potes, Ken Murakami, Jason M. Lavender, Emilio J. Compte, Tiffany A. Brown, Kelsie T. Forbush, Annesa Flentje, Micah E. Lubensky, Juno Obedin‐Maliver, Mitchell R. Lunn   +11 more
wiley   +1 more source

Caught in the fire: An accidental ethnography of discomfort in researching sex work

Feminist Anthropology, EarlyView.
Abstract Drawing on fifteen years of engagement with researching Israel's sex industry, this article uses accidental ethnography to propose discomfort‐as‐method for feminist anthropology. I argue that discomfort is not a by‐product of fieldwork but a constitutive condition that disciplines researchers and shapes what can be known.
Yeela Lahav‐Raz
wiley   +1 more source