Results 141 to 150 of about 60,411 (263)

One‐Pot Gram‐Scale Synthesis of Cynandione A and Detailed Mechanistic Insights into its Regioselectivity

ChemistryOpen, EarlyView.
An improved one‐pot, gram‐scale synthesis of cynandione A, a key natural product from Cynanchi wilfordii Radix with diverse biological activities, has been developed. DFT calculations clarified the regioselectivity of the arylation step in the benzoquinone, revealing that the C3 position of the nucleophile is highly favored due to both kinetic and ...
Jun Sung Kang, Jin Yi Jung, Chan Jae Cho, Seoungwoo Kang, Yeonjoon Kim, Jae Hyun Kim   +5 more
wiley   +1 more source

The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety-Like Behaviors in Rats. [PDF]

Pharmacol Res Perspect
Zhang Y, Zhang W, Yu L, Shi Y, Xu M, Wang H, Li C, Tian J.   +7 more
europepmc   +1 more source

Unveiling the Therapeutic Potential of Atractylis aristata Batt. Aqueous Extract: Anti‐inflammatory, Antioxidant, Antibacterial, Sedative Activities & Phytochemical Profiling

ChemistryOpen, EarlyView.
This study evaluates the pharmacological properties of the aqueous extract of Atractylis aristata, focusing on its antioxidant, anti‐inflammatory, antibacterial, and sedative activities. Phytochemical analysis identifies bioactive compounds, while in vitro and in vivo tests demonstrate its therapeutic potential in addressing oxidative stress ...
Asma Abid, Nourelhouda Mekhadmi, Randa Mlik, Assia Bentahar, Kamilia Bireche, Bariza Frih, Walid Boussebaa, Aicha Mouane, Nezar Cherrada, Ana Sanches Silva, Messaouda Dekmouche, Lazhar Bechki, Khalid Mashay Al‐Anazi, Mohammad Abul Farah, Ahmad Ali   +14 more
wiley   +1 more source

Alterations in Adipokine Levels Are Associated with Human Perinatal Anxiety and Depression. [PDF]

J Clin Med
Camacho-Arroyo I, Flores-Ramos M, Mancilla-Herrera I, Cruz-Coronel FM, Farfan-Labonne B, Jiménez-Aquino LE, Meza-Rodríguez MDP, Hernández-Ruiz J, Leff-Gelman P.   +8 more
europepmc   +1 more source

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

ChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas, Md. Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J. Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam   +8 more
wiley   +1 more source

Essential Oil Profiles of Lippia turbinata (Verbenaceae) from Argentina: Insights from a Systematic Review and Meta‐Analysis

ChemistryOpen, EarlyView.
This study systematically reviews essential oil (EO) profiles of Lippia turbinata (Verbenaceae) populations from Argentina. A meta‐analysis reveals significant chemical variability and distinct chemotypes, primarily defined by limonene, carvone, β‐caryophyllene, and caryophyllene oxide.
Fernando Livio Corzo, Franco Emmanuel Calvo, Emilio Fernando Lizarraga, Guillermo Emilio Marcial, Maria Ines Mercado   +4 more
wiley   +1 more source

Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity. [PDF]

Neuropsychiatr Dis Treat
Kinderlehrer DA.
europepmc   +1 more source

Post‐COVID‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies

The Journal of Pathology, EarlyView.
Abstract Post‐COVID‐19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID‐19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinical manifestations. These manifestations likely arise from diverse underlying pathophysiological mechanisms,
Larissa E Vlaming‐van Eijk, Guolu Tang, Arno R Bourgonje, Wilfred F A den Dunnen, Jan‐Luuk Hillebrands, Harry van Goor   +5 more
wiley   +1 more source

Utilization of Medicinal Plants in Mental Disorders: Neuroplasticity and Neuroprotection in Biomodels. [PDF]

Brain Sci
Estela-Zape JL, Sanclemente-Cardoza V, Noreña-Buitrón LD, Ordoñez-Mora LT.   +3 more
europepmc   +1 more source

Docosahexaenoic acid ameliorates autistic‐like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats

Pediatric Discovery, EarlyView.
The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu, Hao Yuan, Xiaohuan Li, Qingyang Yu, Chunfang Dai, Zhifang Dong   +5 more
wiley   +1 more source