Results 81 to 90 of about 572,169 (326)

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Tactical Use of Biological Weapons for Terrorist Goals [PDF]

Bezbednosni Dijalozi, 2018
The bioterrorist attacks are very efficient and deadly because for a short period of time they cause massive civilian casualties, and achieve psychological fear and anxiety among the general population.
Zlate Dimovski, Ice Ilijevski, Kire Babanoski   +2 more
doaj   +1 more source

Igfbp2 Downregulation in PVT‐CeA Glutamatergic Circuits Drives Neonatal Anesthesia‐Induced Fear Memory Deficits

Advanced Science, EarlyView.
Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao, Ke Peng, Baojian Zhao, Xiaowen Meng, Gang Wang, Hanbing Xu, Li Deng, Xisheng Shan, Yichan Wang, Qiya Xu, Yanan Gao, Ruixia Weng, Hong Liu, Jin Tao, Huayue Liu, Shaoyong Song, Fuhai Ji   +16 more
wiley   +1 more source

Anti-vascular endothelial growth factor in neovascular age-related macular degeneration – a systematic review of the impact of anti-VEGF on patient outcomes and healthcare systems

BMC Ophthalmology, 2020
Background Systematically review the evidence describing the impact of anti–vascular endothelial growth factor (anti-VEGF) therapy on neovascular age-related macular degeneration (nAMD) patient outcomes and healthcare resource utilization.
Robert P. Finger, Vincent Daien, Bora M. Eldem, James S. Talks, Jean-Francois Korobelnik, Paul Mitchell, Taiji Sakamoto, Tien Yin Wong, Krystallia Pantiri, Joao Carrasco   +9 more
doaj   +1 more source

AB1040 CHARACTERIZATION OF ANXIETY AND DEPRESSION AND THEIR IMPACT ON DISEASE ACTIVITY, FATIGUE AND QUALITY OF LIFE IN SPONDYLARTHRITIS PATIENTS TREATED WITH ANTI-TUMOR NECROSIS FACTOR ALPHA AGENTS [PDF]

, 2023
D. Santos Oliveira, A. Martins, Rafaela Nicolau, Carlos Vaz, T. Martins-Rocha, A. Bernardo, M. Bernardes, L. Costa   +7 more
openalex   +1 more source

Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers [PDF]

, 2012
Individual differences in emotional processing are likely to contribute to vulnerability and resilience to emotional disorders such as depression and anxiety.
Anthony S. David, Ayana A. Gibbs, Bradley, Harmer, Kees van Heeringen, Kris H. Naudts, Kucera, Kwang, Moore, Nelson, Routledge, Ruben T. Azevedo, Serretti   +12 more
core   +2 more sources

Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light‐Driven Nanozyme Sensor Array and Machine Learning

Advanced Science, EarlyView.
A novel photoresponsive nanozyme sensor array, combining metal‐organic frameworks (MOFs) with advanced machine learning algorithms, provides a breakthrough in rapid neurotransmitter detection and disease diagnostics. This sensor array is capable of accurately identifying neurotransmitter profiles associated with neurological disorders, offering ...
Kun Yu, Siyuan Lu, Kaiwen Qiu, Yuanzun Zhang, Aobing Sun, Shiqi Gong, Kai Wang, Xuzhu Gao, Xiangyu Xu, Hao Wang   +9 more
wiley   +1 more source

Lateral habenula regulates temporal pattern organization of rat exploratory behavior and acute nicotine-induced anxiety in hole board [PDF]

, 2013
Nicotine is one of the most addictive drugs of abuse. Tobacco smoking is a major cause of many health problems worldwide, and is the first preventable cause of death.
Benigno, Arcangelo, Casarrubea, Maurizio, Cassar, Daniel, Chambers, Stephanie, Colangeli, Roberto, Crescimanno, Giuseppe, Davies, Caitlin, Di Giovanni, Giuseppe, Faulisi, Fabiana, Muscat, Richard, Partdrige, Lucy, Pierucci, Massimo, Valentino, Mario   +12 more
core  

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

PTSD in the 20th Century American Military: Its Diagnosis, Effects, Treatment, and Management, With a Focus on the Vietnam War [PDF]

, 2016
Soldiers have been affected by PTSD for as long as war has existed. The American Military in the twentieth century is no exception. PTSD did not become a diagnosable disease until 1980, and before then it was misdiagnosed as different anxiety disorders ...
Connell, Christy L
core   +1 more source