Results 11 to 20 of about 44,122 (146)

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. [PDF]

, 1999
A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its ...
Antzelevitch, Blumenthal, Busch, Busch, Carmeliet, Carmeliet, Chen, Curran, Daleau, Drici, Duggal, Federico Sesti, Geoffrey W Abbott, Goldstein, Ho, Ho, Howarth, Igor Splawski, Kaczmarek, Katherine W Timothy, Lee, Lees-Miller, Liu, London, Makkar, Marianne E Buck, Mark T Keating, McDonald, Michael H Lehmann, Roden, Roden, Sanguinetti, Sanguinetti, Sanguinetti, Sanguinetti, Scamps, Schulze-Bahr, Sesti, Shibasaki, Smith, Snyders, Spector, Spector, Splawski, Splawski, Steve A.N Goldstein, Tai, Tai, Takumi, Takumi, Trudeau, Tyson, Veldkamp, Vetter, Wang, Wang, Wang, Wang, Wollnik, Yang, Yang, Yang, Yang, Zhou, Zou   +64 more
core   +1 more source

The burden of proof: the current state of atrial fibrillation prevention and treatment trials [PDF]

, 2017
Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from ...
Calkins, Hugh, Cleland, John G.F., Heist, E. Kevin, Kowey, Peter R., Linde, Cecilia, Mentz, Robert J., Meyer, Timothy E., Pitt, Bertram, Ross, Heather M., Van Wagoner, David R., Wong, Tom, Zakeri, Rosita, Zannad, Faiez   +12 more
core   +1 more source

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve [PDF]

, 2012
Background: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti- inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
A Farkas, A Peretz, A Varró, A Varró, A Varró, AJ Batey, Andrea Barbuti, András Varró, Attila Kristóf, B Girennavar, B Scheidel, C Bombardier, C Lengyel, C Lengyel, CL Lawrence, Cs Lengyel, D Corrado, DM Roden, DM Roden, DM Roden, E Coraboeuf, EL Fosbøl, FI Al-Jenoobi, G Hart, HA Bird, István Baczkó, István Koncz, JH Lin, JJ Duncan, Julius Gy Papp, L Carlsson, L Virág, LI Brueggemann, LL von Moltke, LY Liu, László Virág, M Hidaka, M Niemi, MA Vos, N Jost, Norbert Jost, OV Yarishkin, P McGettigan, PG Volders, Péter Biliczki, R Bort, R Varkevisser, S Trelle, T Christ, Tamás Szél, Viktor Juhász, WF Huang, WF Huang, XW Fei, Y Lu, Zoltán Husti, Zsófia Kohajda   +56 more
core   +2 more sources

A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]

, 2001
Low concentrations of certain K_ATP channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
MacKenzie, I., Northover, B.J., Workman, A.J.   +2 more
core   +1 more source

Real-practice thromboprophylaxis in atrial fibrillation [PDF]

, 2017
This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation
Bettiol, Alessandra, Bolcato, Jenny, Chinellato, Alessandro, Deambrosis, Paola, Franchin, Giulia, Giusti, Pietro, Pellizzari, Michele, Pirolo, Roberta, Themistoclakis, Sakis   +8 more
core   +2 more sources

Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]

, 2003
<b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A., Norrie, J., Rankin, A.C., Russell, J.A., Workman, A.J.   +4 more
core   +1 more source

Selecting patients with nonischemic dilated cardiomyopathy for ICDs [PDF]

, 2017
No abstract ...
Cleland, John G.F., Halliday, Brian P., Prasad, Sanjay K.   +2 more
core   +1 more source

Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade [PDF]

, 2003
<b>1.</b> 5-Hydroxytryptamine (5-HT) has been postulated to play a proarrhythmic role in the human atria via stimulation of 5-HT₄ receptors.
Andrew C Rankin, Antony J Workman, BERS, BLONDEL, Davide Pau, DAWODU, GRAMMER, GRIMM, HALL, HEGDE, JAHNEL, JAHNEL, JIA, JOSEPH, KAMATH, Kathleen A Kane, KAUMANN, KAUMANN, KAUMANN, LEVY, MEDHURST, MOE, NATTEL, NEHER, OUADID, RAHME, SANDERS, TONINI, WANG, WANGEMANN, WORKMAN, WORKMAN, YUE   +32 more
core   +2 more sources

Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study) [PDF]

, 2012
<p>Background: The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p> <p>Hypothesis: That chronic oral administration of pimobendan to Dobermans with ...
Boswood, A., Braz-Ruivo, L., Culshaw, G.J., Dukes-McEwan, J., Estrada, A., French, A.T., Gordon, S.G., Loureiro, J., O'Grady, M.R., O'Sullivan, M.L., Oyama, M.A., Patteson, M., Smith, A., Summerfield, N.T., Watson, P.J., Willis, R.   +15 more
core   +1 more source

An evidence-based review of edoxaban and its role in stroke prevention in patients with nonvalvular atrial fibrillation. [PDF]

, 2015
Atrial fibrillation is the most common arrhythmia in the elderly. It is responsible for significant morbidity and mortality from cardioembolic complications like stroke.
Acharya, Tushar, Deedwania, Prakash
core   +1 more source