Results 101 to 110 of about 3,661,773 (260)

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Porcupine‐Quill‐Inspired Shape‐Morphing Biointerfaces Disassemble Biofilms

Advanced Science, EarlyView.
A porcupine‐spine‐inspired dynamic offensive bio‐interface is developed for active biofilm disassembly. By coupling electrically driven nano‐dagger penetration with light‐triggered ROS generation, the surface overcomes the passive limitations of conventional mechano‐bactericidal topographies, achieving near‐complete biofilm eradication, strong ...
Feng Qian, Muqiu Xia, Ziyu Wang, Xinyuan Jia, Jinke Yin, Mengyu Fu, Xue Zhang, Xiao‐Lei Shi, Shiqiang Chen, Ning Wang, Zhi‐Gang Chen   +10 more
wiley   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Liposomes-Based Drug Delivery Systems of Anti-Biofilm Agents to Combat Bacterial Biofilm Formation. [PDF]

Antibiotics (Basel), 2023
Makhlouf Z, Ali AA, Al-Sayah MH.
europepmc   +1 more source

Antimicrobial Agents: Antibacterial Agents, Anti-biofilm Agents, Antibacterial Natural Compounds, and Antibacterial Chemicals

, 2019
إن ظهور مقاومة مضادات الميكروبات إلى جانب انخفاض خط أنابيب الأدوية المضادة للميكروبات يدعو إلى اكتشاف وتطوير عوامل جديدة لمعالجة مقاومة المضادات الحيوية ومنع العودة إلى عصر ما بعد المضادات الحيوية. هناك العديد من العوامل التي تفسر مقاومة الميكروبات ؛ بعضها طبيعي والبعض الآخر مكتسب.
Yaw Duah Boakye, Newman Osafo, Cynthia Amaning Danquah, Francis Adu, Christian Agyare   +4 more
openaire   +2 more sources

Promising Antibiofilm Agents: Recent Breakthrough against Biofilm Producing Methicillin-Resistant Staphylococcus aureus

, 2020
Multidrug resistant (MDR) methicillin-resistant Staphylococcus aureus (MRSA) is a superbug pathogen that causes serious diseases. One of the main reasons for the lack of the effectiveness of antibiotic therapy against infections caused by this resistant ...
Wael A. H. Hegazy, Nabil A. Alhakamy, Wesam H. Abdulaal, El-sayed Y. El-Naenaeey, Mahmoud M. Bendary, Marwa I. Abd El-Hamid, Majed S. Nassar, Toka M kandeel, Rasha A. Mosbah, Muhammed A. Bakhrebah   +9 more
core   +1 more source

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source

Helicobacter pylori Biofilm-Related Drug Resistance and New Developments in Its Anti-Biofilm Agents. [PDF]

Infect Drug Resist, 2022
Hou C, Yin F, Wang S, Zhao A, Li Y, Liu Y.   +5 more
europepmc   +1 more source