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Antimicrobial Peptides as Anti-biofilm Agents in Medical Implants
Current Topics in Medicinal Chemistry, 2016Biofilm-associated infections constitute a daunting threat to human health, since these pathologies increase patient mortality and morbidity, resulting in prolonged hospitalization periods and heavy economic losses. Moreover, these infections contribute to the increasing emergence and dissemination of antibiotic resistance in hospitals and in the ...
Susana, Sánchez-Gómez +1 more
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A REVIEW ON NATURAL ANTI BIOFILM AGENTS FOR WOUND BIOFILM
INDIAN DRUGS, 2021A biofilm may be a consortium of micro-organisms in which the cells of microbes attach to each other on a living or non-living surface inside a self-produced matrix of extracellular polymeric substances. The bacterial or fungal colonies invade the surface of the wounds, thereby delaying the healing cascade.
Mahipriyaa S. R. +4 more
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2017
Biofilms are microbial communities with enhanced interbacterial communication and cooperation. A good knowledge of anti-biofilm options is essential to ensuring correct management and treatment of biofilm-driven infections, with two main interest areas, namely prevention of biofilm formation and eradication of mature biofilm. Wounds can become infected
Oana Săndulescu, Mihai Săndulescu
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Biofilms are microbial communities with enhanced interbacterial communication and cooperation. A good knowledge of anti-biofilm options is essential to ensuring correct management and treatment of biofilm-driven infections, with two main interest areas, namely prevention of biofilm formation and eradication of mature biofilm. Wounds can become infected
Oana Săndulescu, Mihai Săndulescu
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In Vitro Evaluation of Anti-biofilm Agents Against Salmonella enterica
2020Salmonella enterica is able to establish robust adherent communities called biofilms that allow for long-term colonization of both biotic and abiotic surfaces. These biofilm communities pose a significant challenge to successful eradication of the bacteria from contaminated surfaces and the infected host, as entry into the biofilm phenotype confers the
Jenna, Sandala, John S, Gunn
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Anti-biofilm Agents in Control of Device-Related Infections
2014The persistence and relative impermeability of biofilm matrices make the treatment of biofilm-producing organisms much more challenging than the treatment of their planktonic counterparts. However, the challenge is one worth rising towards, as the incidence of biofilm related infectious continues to increase, comprising up to 75 % of all bacterial ...
Salman, Ahmed, Rabih O, Darouiche
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Resveratrol, pterostilbene, and baicalein: plant-derived anti-biofilm agents
Folia Microbiologica, 2017Microbial adhesion to surfaces and the subsequent biofilm formation may result in contamination in food industry and in healthcare-associated infections and may significantly affect postoperative care. Some plants produce substances with antioxidant and antimicrobial properties that are able to inhibit the growth of food-borne pathogens. The aim of our
Kolouchová, I. +9 more
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AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis
2019Microbial cells show a strong natural tendency to adhere to surfaces and to colonize them by forming complex communities called biofilms. In this growth mode, biofilm-forming cells encase themselves inside a dense matrix which efficiently protects them against antimicrobial agents and effectors of the immune system. Moreover, at the physiological level,
Hawraa, Shahrour +6 more
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Micro/nanosystems and biomaterials for controlled delivery of antimicrobial and anti-biofilm agents
Expert Opinion on Therapeutic Patents, 2020Microbial resistance is a severe problem for clinical practice due to misuse of antibiotics that promotes the development of surviving strategies by bacteria and fungi. Microbial cells surrounded by a self-produced polymer matrix, defined as biofilms, are inherently more difficult to eradicate.
Annalisa Bianchera +2 more
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Design and synthesis of dehydrocurvularin analogues as antibacterial and anti-biofilm agents
Bioorganic ChemistryDeveloping highly effective antibacterial agents for treating methicillin-resistant Staphylococcus aureus (MRSA) infections, especially those linked to biofilms, remains a tough problem. Here, we rationally designed and synthesized 30 novel derivatives derived from 10, 11-dehydrocurvularin through biomimetic structural modulation.
Jian-Jia, Liang +8 more
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Natural Anti-Biofilm Agents: A Comprehensive Review and Future Perspectives
Current MicrobiologyBiofilms, complex microbial communities embedded in extracellular polymeric substances (EPS), pose significant challenges across medical, industrial and environmental sectors due to their enhanced resistance to antibiotics and chemical agents. Traditional treatments often fail to combat biofilm-associated infections, leading to increased healthcare ...
Sivakamavalli, Jeyachandran +1 more
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