Results 241 to 250 of about 3,484,912 (268)

Micro/nanosystems and biomaterials for controlled delivery of antimicrobial and anti-biofilm agents

Expert Opinion on Therapeutic Patents, 2020
Microbial resistance is a severe problem for clinical practice due to misuse of antibiotics that promotes the development of surviving strategies by bacteria and fungi. Microbial cells surrounded by a self-produced polymer matrix, defined as biofilms, are inherently more difficult to eradicate.
Bianchera, Annalisa, Buttini, Francesca, Bettini, Ruggero   +2 more
openaire   +3 more sources

Design and synthesis of dehydrocurvularin analogues as antibacterial and anti-biofilm agents

Bioorganic Chemistry
Developing highly effective antibacterial agents for treating methicillin-resistant Staphylococcus aureus (MRSA) infections, especially those linked to biofilms, remains a tough problem. Here, we rationally designed and synthesized 30 novel derivatives derived from 10, 11-dehydrocurvularin through biomimetic structural modulation.
Jian-Jia, Liang, Fei-Yu, Pang, Yuan-Zhang, Li, Hong-Yue, Ma, Na, Peng, Lu, Ran, Ai-Yang, Liu, Li-Li, Zou, Zhang-Shuang, Deng   +8 more
openaire   +2 more sources

Natural Anti-Biofilm Agents: A Comprehensive Review and Future Perspectives

Current Microbiology
Biofilms, complex microbial communities embedded in extracellular polymeric substances (EPS), pose significant challenges across medical, industrial and environmental sectors due to their enhanced resistance to antibiotics and chemical agents. Traditional treatments often fail to combat biofilm-associated infections, leading to increased healthcare ...
Sivakamavalli, Jeyachandran, Sasikala, Sekar   +1 more
openaire   +2 more sources

Investigation of Fungal Extracts as Anti-Biofilm Agents

Many nosocomial infections are derived from microbial growth on implantable medical devices that form biofilms. Biofilms are complex colonies of bacteria that can grow on the surfaces of medically implantable devices and typically have antibiotic-resistant properties. Currently, no commercially available FDA-approved or EPA-certified biofilm sterilants
Bao, Lili, Cardillo, Andrew, Chowdhury, Ranita, Crowley, Leah, Eldo, Annette, Gibney, Catalina, Gul, Beyza, Kong, Matthew, Meda, Anju, Meyers, Sumangal   +9 more
openaire   +1 more source

GREEN ANTI-BIOFILM AGENTS: A MINI-REVIEW

INDIAN JOURNAL OF APPLIED RESEARCH
Microbial biolm is the polymeric matrix formed by coordinated assembly of species of similar or different microorganisms. The bacteria in form of biolms are more resistant to drugs than compared to their planktonic counterparts, hence making it difcult to deal with biolm-associated nosocomial and medical device infections.
openaire   +1 more source

Bioprospecting Novel Antifoulants and Anti-Biofilm Agents from Microbes

2014
Fouling on the surfaces of ships or other submerged structures results in corrosion, a decrease in hydrodynamic efficiency, transport of introduced pests, and many other problems worldwide. Fouling generally occurs in a predictable sequence, with colonization by bacteria and biofilm formation happening in hours to days followed by colonization of ...
Carola Holmström, Peter Steinberg, Staffan Kjelleberg   +2 more
openaire   +1 more source

Enterococcus Phage vB_EfaS_HEf13 as an Anti-Biofilm Agent Against Enterococcus faecalis

Journal of Microbiology
Enterococcus faecalis is a Gram-positive bacterium that is frequently found in the periapical lesion of patients with apical periodontitis. Its biofilm formation in root canal is closely related to the development of refractory apical periodontitis by providing increased resistance to endodontic treatments. Phage therapy has recently been considered as
Dongwook Lee, Jintaek Im, A Reum Kim, Woohyung Jun, Cheol-Heui Yun, Seung Hyun Han   +5 more
openaire   +2 more sources

[Advances in the study of synergistic effect of anti-biofilm agents].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
Biofilms are communities of surface-associated bacteria or fungi embedded in a self-produced extracellular polymeric matrix that are notoriously difficult to be eradicated and are sources of many recalcitrant infections. Treatment for biofilm infection with any individual drug is always less effective, while the combinations of different types of drugs
Chang-Zhong, Wang, Hui-Juan, Cheng
openaire   +1 more source

Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation

Expert Opinion on Therapeutic Patents, 2015
Nanoparticles based on poly(dimethylaminoethyl methacrylate)-b-poly(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate) (p-DMAEMA-b-(DMAEMA-co-PAA-co-BMA)) were loaded with farnesol or apigenin for the controlled, pH-dependent release of the two agents to inhibit pathogenic bacteria-producing biofilms. The inventions are mainly
openaire   +2 more sources

Helicobacter pylori Biofilm-Related Drug Resistance and New Developments in Its Anti-Biofilm Agents

Infection and Drug Resistance, 2022
Chong Hou, Fang-Xu Yin, Song Wang
exaly