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Investigation of Fungal Extracts as Anti-Biofilm Agents
Many nosocomial infections are derived from microbial growth on implantable medical devices that form biofilms. Biofilms are complex colonies of bacteria that can grow on the surfaces of medically implantable devices and typically have antibiotic-resistant properties. Currently, no commercially available FDA-approved or EPA-certified biofilm sterilantsBao, Lili +9 more
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Enterococcus Phage vB_EfaS_HEf13 as an Anti-Biofilm Agent Against Enterococcus faecalis
Journal of MicrobiologyEnterococcus faecalis is a Gram-positive bacterium that is frequently found in the periapical lesion of patients with apical periodontitis. Its biofilm formation in root canal is closely related to the development of refractory apical periodontitis by providing increased resistance to endodontic treatments. Phage therapy has recently been considered as
Dongwook Lee +5 more
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Bioprospecting Novel Antifoulants and Anti-Biofilm Agents from Microbes
2014Fouling on the surfaces of ships or other submerged structures results in corrosion, a decrease in hydrodynamic efficiency, transport of introduced pests, and many other problems worldwide. Fouling generally occurs in a predictable sequence, with colonization by bacteria and biofilm formation happening in hours to days followed by colonization of ...
Carola Holmström +2 more
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Structure–Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents
Journal of Medicinal Chemistry, 2017Pseudomonas aeruginosa is a causative agent of chronic infections in immunocompromised patients. Disruption of quorum sensing circuits is an attractive strategy for treating diseases associated with P. aeruginosa infection. In this study, we designed and synthesized a series of gingerol analogs targeting LasR, a master regulator of quorum sensing ...
Hyunsuk Choi +8 more
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GREEN ANTI-BIOFILM AGENTS: A MINI-REVIEW
INDIAN JOURNAL OF APPLIED RESEARCHMicrobial biolm is the polymeric matrix formed by coordinated assembly of species of similar or different microorganisms. The bacteria in form of biolms are more resistant to drugs than compared to their planktonic counterparts, hence making it difcult to deal with biolm-associated nosocomial and medical device infections.
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[Advances in the study of synergistic effect of anti-biofilm agents].
Yao xue xue bao = Acta pharmaceutica Sinica, 2013Biofilms are communities of surface-associated bacteria or fungi embedded in a self-produced extracellular polymeric matrix that are notoriously difficult to be eradicated and are sources of many recalcitrant infections. Treatment for biofilm infection with any individual drug is always less effective, while the combinations of different types of drugs
Chang-Zhong, Wang, Hui-Juan, Cheng
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Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis
Biofouling, 2018Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to ...
Ricciardelli, Annarita +10 more
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Infectious Disorders - Drug Targets
Multicellular surface-attached populations of bacteria embedded in the extracellular matrix are known as biofilms. Bacteria generally preferred to grow as biofilms. Quorum sensing (QS), detection of density of cell population through gene regulation, has been found to play an important role in the production of biofilms.
Debolina Banerjee +6 more
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Multicellular surface-attached populations of bacteria embedded in the extracellular matrix are known as biofilms. Bacteria generally preferred to grow as biofilms. Quorum sensing (QS), detection of density of cell population through gene regulation, has been found to play an important role in the production of biofilms.
Debolina Banerjee +6 more
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Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation
Expert Opinion on Therapeutic Patents, 2015Nanoparticles based on poly(dimethylaminoethyl methacrylate)-b-poly(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate) (p-DMAEMA-b-(DMAEMA-co-PAA-co-BMA)) were loaded with farnesol or apigenin for the controlled, pH-dependent release of the two agents to inhibit pathogenic bacteria-producing biofilms. The inventions are mainly
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Helicobacter pylori Biofilm-Related Drug Resistance and New Developments in Its Anti-Biofilm Agents
Infection and Drug Resistance, 2022Chong Hou, Fangxu Yin, Song Wang
exaly