Results 71 to 80 of about 5,298,732 (170)

Meta-Analysis: Diagnostic Accuracy of Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis

PLOS ONE, 2016
The anti-carbamylated protein (CarP) antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis (RA). We aim to assess the diagnostic value of anti-CarP antibody for RA.We systematically searched PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for studies published by December 15, 2015.
Li, Liubing, Deng, Chuiwen, Chen, Si, Zhang, Shulan, Wu, Ziyan, Hu, Chaojun, Zhang, Fengchun, Li, Yongzhe   +7 more
openaire   +5 more sources

Improved diagnosis of rheumatoid arthritis using an artificial neural network

Scientific Reports, 2022
Rheumatoid arthritis (RA) is chronic systemic disease that can cause joint damage, disability and destructive polyarthritis. Current diagnosis of RA is based on a combination of clinical and laboratory features.
Linlu Bai, Yuan Zhang, Pan Wang, Xiaojun Zhu, Jing-Wei Xiong, Liyan Cui   +5 more
doaj   +1 more source

Added value of multiple autoantibody testing for predicting progression to inflammatory arthritis in at-risk individuals

RMD Open, 2022
Background Predicting progression to clinical arthritis in individuals at-risk of developing rheumatoid arthritis is a prerequisite to developing stratification groups for prevention strategies. Selecting accurate predictive criteria is the critical step
Paul Emery, K Mankia, Laurence Duquenne, Farag Shuweihdi, L A Trouw, Frederique Ponchel, Diane Corscadden, Xuanxiao Xie   +7 more
doaj   +1 more source

AB0347 CLINICAL RELEVANCE OF ANTI-CARBAMYLATED PROTEIN ANTIBODY: IS IT SAME AS CAUCASIANS IN ASIANS? [PDF]

Annals of the Rheumatic Diseases, 2019
Background Recently, there was an interesting study demonstrating that anti-CarP was associated with more inflammation and higher baseline disease activity in French ESPOIR cohort [1]. However, all of the investigated patient cohorts have been Caucasian.
Jung Yoon Pyo, Seungmin Jung, Sangwon Lee, Jason Jungsik Song, Yongbeom Park   +4 more
openaire   +1 more source

Specific association of HLA-DRB1*03 with anti-carbamylated protein antibodies in patients with rheumatoid arthritis [PDF]

, 2019
[Objective]: Recognition of a new type of rheumatoid arthritis (RA)-specific autoantibody, the anti-carbamylated protein antibodies (anti-CarP), has provided an opportunity to improve the management and understanding of RA.
Juan J. Gomez‐Reino, Eva Pérez‐Pampín, Alejandro Balsa, Castaño-Núñez, Ángel L., Cristina Regueiro, Herranz, Eva, María Dolores Boveda, Gómez-Reino, Juan J., Yolanda Lopez‐Golan, Ana M. Ortiz, Antonio González, Lydia Abasolo, Balsa, Alejandro, Nuño, Laura, Abasolo, Lydia, Martín, Javier, Laura Nuño, Angel L. Castaño‐Nuñez, Isodoro González‐Álvaro, Fernández-Gutiérrez, Benjamín, Triguero-Martínez, Ana, Javier Martín, María Francisca Gonzalez‐Escribano, Rodríguez-Rodríguez, Luis, López-Golan, Yolanda, González-Escribano, María Francisca, Regueiro, Cristina, Eva Herranz, Villalva, Alejandro, Ortiz, Ana M., Boveda, María Dolores, Pérez-Pampin, Eva, González, Antonio, Ana Triguero‐Martinez, Luis Rodríguez‐Rodríguez, González-Álvaro, Isidoro, Alejandro Villalva, Benjamín Fernández‐Gutiérrez, Martínez-Feito, Ana, Ana Martínez‐Feito, Pascual-Salcedo, Dora, Dora Pascual‐Salcedo   +41 more
core   +1 more source

Evaluating the Diagnostic Accuracy of Rheumatoid Factor, Anti-citrullinated Protein Antibody and Anti-carbamylated Protein Antibody in Early Detection of Rheumatoid Arthritis: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Rheumatoid Arthritis (RA) is a systemic autoimmune disease that primarily affects synovial joints. Joint infiltration with immune cells is a characteristic feature of RA.
Karthiga Dhakshna Murthi, Anusha Gopinathan, Leela Kakithakara Vajravelu, Thilagam Ramasamy   +3 more
doaj   +1 more source

C-reactive protein is essential for innate resistance to pneumococcal infection. [PDF]

, 2014
No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known.
Lawrence, Rachel A., Read, Kevin D., Aviva Petrie, Pepys, M B, Pepys, MB, Hutchinson, Winston L., LSHTM, Read, Kevin D, Raynes, JG, Read, KD, J. Brian Souza, Tennent, G A, Stephan Ellmerich, Loeffler, JM, Simons, JP, Rachel A. Lawrence, Simons, J Paul, Tennent, GA, John G. Raynes, Dundee, Glenys A. Tennent, Ellmerich, Stephan, Ellmerich, S, Tennent, Glenys A, Al-Shawi, Raya, Petrie, A, Tennent, Glenys A., Simons, J. Paul, Lawrence, R A, Jutta M. Loeffler, Lawrence, RA, Hutchinson, Winston L, J. Paul Simons, de Souza, J Brian, de Souza, J. Brian, Kevin D. Read, Raynes, John G., Raynes, J G, Read, K D, Mark B. Pepys, Hutchinson, WL, de Souza, JB, Loeffler, Jutta M, Petrie, Aviva, Al-Shawi, R, Pepys, Mark B., Lawrence, Rachel A, Raynes, John G, Loeffler, J M, de Souza, J B, Hutchinson, W L, Pepys, Mark B, Raya Al‐Shawi, Winston L. Hutchinson, Loeffler, Jutta M., Simons, J P, UCL   +56 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Anti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides

Diagnostics
Background/Objectives. The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide ...
Isabel Haro, Raul Castellanos-Moreira, Raimon Sanmartí, María José Gómara   +3 more
doaj   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source