Results 141 to 150 of about 72,428 (256)

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

open access: yesExploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li   +23 more
wiley   +1 more source

Effect of Microchannel Geometry on Nanoparticle Deposition in Nanofluid Flow

open access: yesInternational Journal for Numerical Methods in Fluids, EarlyView.
This study numerically analyzed nanoparticle deposition in microchannels with varying geometries. Deposition per unit area decreases significantly with increasing bend angle (28.612 to 8.941 between 30° and 120°) and bend radius (11.922 to 4.769 between 0.2 and 0.4 mm). Acute bends and small radii enhance centrifugal forces and flow separation, leading
Meng Wang   +3 more
wiley   +1 more source

On the Variability of Results for Cylinder Flow: A Systematic Analysis of Parameter Sensitivity Within the Lattice Boltzmann Method

open access: yesInternational Journal for Numerical Methods in Fluids, EarlyView.
This study systematically investigates the variability of cylinder flow results. We provide a comprehensive overview of literature values and, using the lattice Boltzmann method (LBM), show that insufficient convergence studies and variations in simulation parameters are a plausible cause for the significant spread in data.
Maximilian Bille   +4 more
wiley   +1 more source

Triboelectric nanogenerators for vehicle intelligent cockpits

open access: yesFlexMat, EarlyView.
Converting mechanical stimuli from drivers and vehicle motion into electrical signals, triboelectric nanogenerators provide promising interfaces toward passive, flexible, distributed and intelligent sensing for next‐generation automotive cockpits to support three core functional dimensions: driver state monitoring, vehicle state monitoring, and human ...
Haiqiu Tan   +9 more
wiley   +1 more source

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

open access: yesiMeta, EarlyView.
A prognosis‐oriented classification system was established to distinguish Pachy PCV from Non‐pachy PCV using a large multicenter dataset. Comparative plasma multi‐omics profiling of Pachy PCV, Non‐pachy PCV, and normal controls revealed unique upregulation of the fluid shear stress and atherosclerosis (FSS‐AS) and HIF‐1 signaling pathways in Pachy PCV.
Xinyu Zhao   +18 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

open access: yesInterdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu   +6 more
wiley   +1 more source

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