Results 151 to 160 of about 72,138 (302)

Biosensing With Nanofluidics

open access: yesExploration, EarlyView.
Nanofluidic biosensors employing in‐plane, out‐of‐plane, and free‐plane architectures transduce biomolecular information into fluidic signals through nanoscale manipulation of confined fluids, offering a quantitative and highly sensitive platform for biochemical detection. ABSTRACT Nanofluidics, the study of fluid transport confined within nanochannels
Qun Ma, Yan Xu
wiley   +1 more source

Recent advances in multifunctional soft robots: A materials–structures–systems co‐design perspective for synergistic integration

open access: yesFlexMat, EarlyView.
Abstract Soft robots, engineered from highly compliant materials, offer superior adaptability and safety in unstructured environments compared to their rigid counterparts. Recent advancements, fueled by bio‐inspiration and material programmability, have led to the rapid co‐evolution of their core modules: actuation, sensing, protection, energy, and ...
Qiulei Liu   +3 more
wiley   +1 more source

Simultaneous Quantification of Phenolic Compounds and Capsaicinoids in Chili Peppers Using Ultra‐High Performance Liquid Chromatography‐Tandem Mass Spectrometry

open access: yesFood Safety and Health, EarlyView.
A UHPLC‐MS/MS method was developed to simultaneously quantify four capsaicinoids and 19 phenolic compounds, the key bioactive constituents in chili peppers. It exhibits high sensitivity, low matrix effects, excellent accuracy, and precision, enabling reliable detection in chili samples.
Shaoyun Wu   +10 more
wiley   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

open access: yesiMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian   +13 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

open access: yesInterdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu   +6 more
wiley   +1 more source

The Alignment Risks of AI Overconfidence about Consciousness

open access: yesJournal of Applied Philosophy, EarlyView.
ABSTRACT Many contemporary AI systems (as of May 2025) have expressed extreme confidence in current and near‐future AI lacking consciousness and moral patiency. This article argues that artificially reinforcing such confidence, even if pragmatically useful, poses a novel alignment risk: as coherence‐seeking AIs become more epistemically principled ...
Sharon Berry
wiley   +1 more source

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