Therapeutic Advances in Gastroenterology, 2021 Anti-drug antibodies can interfere with the activity of anti-tumor necrosis factor (TNF) agents by increasing drug clearance via direct neutralization.
Sonia Facchin +10 more
doaj +2 more sources
Dynamics and implications of anti-drug antibodies against adalimumab using ultra-sensitive and highly drug-tolerant assays [PDF]
Frontiers in ImmunologyBackgroundAdalimumab induces the production of anti-drug antibodies (ADA) that may lead to reduced drug concentration and loss-of-response, posing significant clinical challenges. However, traditional immunoassays have limitations in terms of sensitivity
Xiaoliang Ding +17 more
doaj +2 more sources
Detection of infliximab, adalimumab, and anti-drug antibodies: Development and validation of new monotest, automated assays on multiparametric instrument [PDF]
Practical Laboratory MedicineObjective: To convert manual ELISA kits to fully automated immunoassays that quantify serum drug levels and anti-drug antibodies levels of infliximab and adalimumab (CHORUS Promonitor kits).
Helena Cerutti +8 more
doaj +2 more sources
Anti-Drug Antibodies in the Biological Therapy of Autoimmune Rheumatic Diseases [PDF]
Journal of Clinical Medicine, 2023 Ana Laura Márquez-Aguirre +2 more
exaly +2 more sources
Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody [PDF]
MAbs, 2022 Richard Vandlen +2 more
exaly +2 more sources
Frontiers in Medicine, 2021 Background: Anti-drug antibodies to infliximab (ATI) and adalimumab (ATA) are associated with loss of response to tumor necrosis factor antagonist (anti-TNF) therapy in inflammatory bowel disease (IBD).
Mohammad Shehab +7 more
doaj +1 more source
Immunogenicity and Lupus-Like Autoantibody Production Can Be Linked to Each Other along With Type I Interferon Production in Patients with Rheumatoid Arthritis Treated With Infliximab: A Retrospective Study of a Single Center Cohort. [PDF]
PLoS ONE, 2016 Besides anti-drug antibodies, anti-nuclear antibodies and anti-DNA antibodies are often induced in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors.
Yuki Ishikawa +8 more
doaj +1 more source
ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS [PDF]
Romanian Journal of Rheumatology, 2016 Objective. The purpose of the present study was to assess the relevance of therapeutic drug monitoring in spondyloarthritis patients, by determining drug serum levels and anti-drug antibodies and estimating cut-off values for three TNF inhibitors ...
Claudia Deaconu +2 more
doaj +1 more source
Application of In vitro transcytosis models to brain targeted biologics.
PLoS ONE, 2023 The blood brain barrier (BBB) efficiently limits the penetration of biologics drugs from blood to brain. Establishment of an in vitro BBB model can facilitate screening of central nervous system (CNS) drug candidates and accelerate CNS drug development ...
Kangwen Deng +6 more
doaj +2 more sources
Anti-TNF-α Drugs Differently Affect the TNFα-sTNFR System and Monocyte Subsets in Patients with Psoriasis. [PDF]
PLoS ONE, 2016 TNF-α has a central role in the development and maintenance of psoriatic plaques, and its serum levels correlate with disease activity. Anti-TNF-α drugs are, however, ineffective in a relevant percentage of patients for reasons that are currently unknown.
Lara Gibellini +14 more
doaj +1 more source