Results 21 to 30 of about 4,527,801 (246)

Rapid modification of antibodies on the surface of liposomes composed of high-affinity protein A-conjugated phospholipid for selective drug delivery

Biochemistry and Biophysics Reports, 2021
Antibody-modified liposomes, immuno-liposomes, can selectively deliver encapsulated drug ‘cargos’ to cells via the interaction of cell surface proteins with antibodies.
Susumu Hama, Mika Sakai, Shoko Itakura, Eiji Majima, Kentaro Kogure   +4 more
doaj   +1 more source

Emerging paradigms in anti-infective drug design. [PDF]

, 2014
The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L, Barrett, Michael P., Barrett, Michael P, Croft, Simon L.   +3 more
core   +1 more source

The development and applications of polyclonal and monoclonal antibodies for the detection of illicit drugs in saliva samples [PDF]

, 2002
Anti-tetrahydrocannabinol (THC), anti-cocaine and anti-morphine polyclonal antibodies were produced. These antibodies were successfully applied to an ELISA format for the detection of THC, cocaine, and morphine in saliva samples. Monoclonal antibodies
Fanning, Lorna M.
core   +2 more sources

Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Communications Chemistry, 2022
Methoxy polyethylene glycol (mPEG) is widely attached to drug molecules to improve their therapeutic efficacy, however mPEG can induce anti-PEG antibodies that negatively impact their therapeutic effects.
Minh-Tram T. Nguyen, Yu-Chien Shih, Meng-Hsuan Lin, Steve R. Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su   +10 more
doaj   +1 more source

Anti-neurofascin antibodies [PDF]

, 2012
Neurofascin (NF) is a cell-adhesion molecule that is found at the nodes of Ranvier. The 186 kDa isoform of neurofascin (NF186) is expressed on the axon in the exposed node, and the 155 kDa isoform (NF155) is expressed on myelinating glia at the ...
Ng, King Man
core   +1 more source

Higher body mass index and anti-drug antibodies predict the discontinuation of anti-TNF agents in Korean patients with axial spondyloarthritis

Revista Brasileira de Reumatologia
Objective: The development of anti-drug antibodies against tumor necrosis factor inhibitors is a likely explanation for the failure of TNF-inhibitors in patients with spondyloarthritis.
Jiwon Hwang, Hye-Mi Kim, Hyemin Jeong, Jaejoon Lee, Joong Kyong Ahn, Eun-Mi Koh, Eun-Suk Kang, Hoon-Suk Cha   +7 more
doaj   +1 more source

INVESTIGATION OF A ROLE OF THE IMMUNOGENICITY OF INFLIXIMAB IN THE THERAPY OF ANKYLOSING SPONDYLITIS

Научно-практическая ревматология, 2016
At present, there are a number of unsolved problems associated with unawareness of the causes and ways to prevent the inefficacy of tumor necrosis factor-α  inhibitors.Objective: to study the causes of secondary inefficacy of infliximab (INF), by ...
O. A. Rumyantseva, A. G. Bochkova, M. M. Urumova, M. V. Cherkasova, E. N. Aleksandrova, S. K. Solovyev, Sh. F. Erdes   +6 more
doaj   +1 more source

Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11 [PDF]

, 2010
Background: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barre syndrome (GBS) patients and are probably induced by molecular mimicry.
Dijkstra, J.R. (Jeroen), LS Klinisch Onderzoek Wagenaar, Endtz, Hubert Ph, Ang, CW (Wim), Hubert Ph Endtz, Wagenaar, J.A., Jeurissen, Suzan H M, de Klerk, M.A., Jacobs Bart C., van Doorn, Pieter; id_orcid, Endtz Hubert Ph., Jacobs, B.C. (Bart), Endtz, Hubert, Klerk, M.A. de, Bart C Jacobs, van Doorn Pieter A., Dijkstra Jeroen R., Klerk, M.A., de, Jeurissen, P.P.T. (Patrick), Wagenaar Jaap A., de Klerk, MA, Ang, C.W., Jeurissen, SHM, Doorn, P.A., Marcel A de Klerk, Wagenaar, J.A. (Jaap), Endtz, H.P., Doorn, P.A. (Pieter) van, Doorn, P.A. van, Jacobs, B.C., Ang C. Wim, de Klerk Marcel A., Suzan H M Jeurissen, Dijkstra, JR, van Doorn, P.A., Dijkstra, J.R., Jaap A Wagenaar, Ang, C Wim, Dijkstra, Jeroen R, Wagenaar, JA, Jacobs, Bart C, Jeurissen, S.H.M., C Wim Ang, Jeroen R Dijkstra, Endtz, H.P. (Hubert), Wagenaar, Jaap A, de Klerk, Marcel A, Pieter A van Doorn, Ang, C.W. (Wim), van Doorn, Pieter A, Jeurissen Suzan H. M.   +50 more
core   +3 more sources

The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment With Monoclonal Antibodies

Frontiers in Immunology, 2020
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine, however, the repeated administration of mAbs can be highly immunogenic.
Anna Vaisman-Mentesh, Matias Gutierrez-Gonzalez, Brandon J. DeKosky, Brandon J. DeKosky, Yariv Wine   +4 more
doaj   +1 more source

Adverse side-effects of biological agents: Hypersensitivity reactions [PDF]

Arhiv za farmaciju, 2014
Clinical use of various biological agents (protein-based products derived from biological sources, such as bacteria, fungi or mammalian cells) have greatly improved the treatment of a wide variety of diseases in humans.
Stojić-Vukanić Zorica, Arsenović-Ranin Nevena, Antić-Stanković Jelena, Milenković Marina   +3 more
doaj   +1 more source