Results 1 to 10 of about 2,254,901 (137)

GnRH Vaccine Could Suppress Serum Testosterone in Stallion Mules [PDF]

Animals
Stallion mules have been used as working equids in several countries. Aggressiveness under the influence of testosterone results in the necessity for surgical castration before work training.
Siriporn Khumsap, Sahatchai Tangtrongsup, Patcharapa Towiboon, Chaleamchat Somgird   +3 more
doaj   +5 more sources

Influence of Humoral Response Against GnRH, Generated by Immunization with a Therapeutic Vaccine Candidate on the Evolution of Patients with Castration-Sensitive Prostate Adenocarcinoma

Technology in Cancer Research & Treatment, 2023
Background and aims A gonadotropin-releasing hormone (GnRH)-based therapeutic vaccine candidate against hormone-sensitive prostate cancer has demonstrated its safety and signs of efficacy in phase I/II trials.
Ana Cristina Campal-Espinosa PhD, Jesús Arturo Junco-Barranco PhD, Franklin Fuentes-Aguilar MSc, Lesvia Calzada-Aguilera BSc, Annia Rivacoba-Betancourt MD, Ranfis Humberto Rodríguez-Bueno MD, Ana Claudia Bover-Campal MD, Eddy Emilio Bover-Fuentes MSc, Lourdes González BSc, Lourdes de Quesada MSc, Allelin Alvarez BSc, Hilda Elisa Garay-Pérez PhD   +11 more
doaj   +2 more sources

Dose-dependent effects of a recombinant gonadotropin-releasing hormone vaccine on reproductive function and growth performance in male goats [PDF]

Animal Bioscience
Objective This study aimed to develop a recombinant gonadotropin-releasing hormone (GnRH) vaccine and to investigate the effects of different immunization doses on immunocastration efficacy and growth performance in male goats; thererby providing an ...
Fuqiang Pan, Mengdi Han, Wei Qian, Yuke Jia, Hongyan Liao, Weina Li, Ziyi Zheng, Ruonan Yuan, Chunyan Yuan, Fugui Fang, Yunsheng Li, Yinghui Ling, Hongwei Duan, Ya Liu   +13 more
doaj   +2 more sources

A Novel GnRH-Based Immunocastration Vaccine Modulates Growth, Reproductive and Meat Quality Traits in Male Leizhou Goats [PDF]

Animals
Castration is widely used in goat production to improve meat quality and manage reproduction, yet conventional surgical methods raise significant animal welfare concerns. Immunocastration targeting gonadotropin-releasing hormone (GnRH) offers a promising,
Mengzhen Luo, Liqin Han, Yueming Yuan, Liuxia Lin, Da Feng, Siyi Hu, Mei Zhou, Namula Zhao, Rui Gao, Shangquan Gan   +9 more
doaj   +2 more sources

Immunocastration with recombinant GnRH6-CRM197 fusion protein improves reproductive suppression and meat tenderness in roosters [PDF]

Poultry Science
This study evaluated the potential of the recombinant GnRH6-CRM197 fusion protein as an immunocastration vaccine for roosters. Forty 4-week-old roosters were divided into two groups: the immune group and the control group that received a saline injection.
Mengxian Li, Kejian Han, Dongyuan Fu, Rui Zhang, Xiangyang Jiang, Juntai Lu, Yuxin Yan, Junhong Li, Ya Liu, Yunsheng Li, Tong Yu, Hongwei Duan, Fugui Fang   +12 more
doaj   +2 more sources

Immunogenicity and Contraceptive Potential of a Classical Swine Fever Viral Vector Live Vaccine Strain Containing Pig Gonadotropin-Releasing Hormone [PDF]

Vaccines
Background: Classical swine fever virus (CSFV) is a highly contagious and fatal disease in pigs and wild boars. While hunting and bait vaccination are effective for CSFV eradication, additional strategies are needed to control wild boar populations. This
Dong-Jun An, Ji-Hee Shin, SeEun Choe, Young-Hyeon Lee, Min-Kyung Jang, Byung-Hyun An, Gyu-Nam Park, Yun-Sang Cho, Kyung-Soo Chang   +8 more
doaj   +2 more sources

Preparation and Immunogenicity Evaluation of a Ferritin-Based GnRH Nanoparticle Vaccine [PDF]

Vaccines
Objectives: Research on the immunocastration vaccine is of great significance for animal management. In this study, the gonadotropin-releasing hormone (GnRH) ferritin nanoparticle vaccine was constructed using Spy Catcher-Spy Tag (SC-ST) as a delivery ...
Ying Xu, Weihao Zhao, Yuhan Zhu, Bo Sun, Congmei Wu, Yuhe Yin   +5 more
doaj   +2 more sources

Short Term Safety, Immunogenicity, and Reproductive Effects of Combined Vaccination With Anti-GnRH (Gonacon) and Rabies Vaccines in Female Feral Cats

Frontiers in Veterinary Science, 2021
Overpopulation of free-roaming cats is a major problem leading to negative impacts on animal health and welfare, public nuisance, transmission of zoonotic diseases, and well-documented harm to wildlife.
Shiri Novak, Boris Yakobson, Shir Sorek, Liat Morgan, Smadar Tal, Ran Nivy, Roni King, Lauren Jaebker, Douglas C. Eckery, Tal Raz   +9 more
doaj   +3 more sources

Reproductive parameters of lambs immunocastrated with anti-GnRH vaccine. [PDF]

Anim Reprod, 2021
Rocha LF, Souza RS, Santana ALA, Macedo DS, Santana AMS, da Silva RC, Bezerra PA, de Jesus RDL, Barbosa LP.   +8 more
europepmc   +2 more sources

Effect of a single or two doses of an anti-GnRH vaccine on testicle morpho-functional characteristics in Nelore bulls. [PDF]

Trop Anim Health Prod, 2021
Doroteu EM, Viana JHM, Ferreira Junior JA, Macedo JTA, Oliveira RA, Pedroso PMO.   +5 more
europepmc   +2 more sources