GnRH Vaccine Could Suppress Serum Testosterone in Stallion Mules [PDF]
AnimalsStallion mules have been used as working equids in several countries. Aggressiveness under the influence of testosterone results in the necessity for surgical castration before work training.
Sahatchai Tangtrongsup +2 more
exaly +5 more sources
Induction of immunocontraceptive effects in both male and female mice immunized with GnRH vaccine [PDF]
Veterinary Medicine and Science, 2021 Background Gonadotropin‐releasing hormone (GnRH) plays a pivotal role in regulating the reproductive endocrine system. Objective An immunocontraception vaccine aimed at inhibiting the functions of GnRH is tested as a potential tool for controlling animal
Dong-Hwi Kim +2 more
exaly +3 more sources
Polyacrylate-GnRH Peptide Conjugate as an Oral Contraceptive Vaccine Candidate
Pharmaceutics, 2021 Contraceptive vaccines are designed to elicit immune responses against major components of animal reproductive systems. These vaccines, which are most commonly administered via injection, typically target gonadotropin-releasing hormone (GnRH).
Mariusz Skwarczyński +2 more
exaly +4 more sources
Preparation and Immunogenicity Evaluation of a Ferritin-Based GnRH Nanoparticle Vaccine [PDF]
VaccinesObjectives: Research on the immunocastration vaccine is of great significance for animal management. In this study, the gonadotropin-releasing hormone (GnRH) ferritin nanoparticle vaccine was constructed using Spy Catcher-Spy Tag (SC-ST) as a delivery ...
Bo Sun
exaly +4 more sources
Technology in Cancer Research and Treatment, 2023 Background and aims A gonadotropin-releasing hormone (GnRH)-based therapeutic vaccine candidate against hormone-sensitive prostate cancer has demonstrated its safety and signs of efficacy in phase I/II trials.
Ana Campal
exaly +2 more sources
Dose-dependent effects of a recombinant gonadotropin-releasing hormone vaccine on reproductive function and growth performance in male goats [PDF]
Animal BioscienceObjective This study aimed to develop a recombinant gonadotropin-releasing hormone (GnRH) vaccine and to investigate the effects of different immunization doses on immunocastration efficacy and growth performance in male goats; thererby providing an ...
Fuqiang Pan +13 more
doaj +2 more sources
Advances and future applications of immunocastration techniques: a comprehensive review [PDF]
npj VaccinesImmunocastration uses antigen-antibody interactions to suppress reproductive function without surgery. This review examines vaccines targeting GnRH, zona pellucida (ZP), and sperm antigens, focusing on GnRH vaccine platforms, carriers, adjuvants, and ...
Mingshuo Ji +7 more
doaj +2 more sources
A Novel GnRH-Based Immunocastration Vaccine Modulates Growth, Reproductive and Meat Quality Traits in Male Leizhou Goats [PDF]
AnimalsCastration is widely used in goat production to improve meat quality and manage reproduction, yet conventional surgical methods raise significant animal welfare concerns. Immunocastration targeting gonadotropin-releasing hormone (GnRH) offers a promising,
Mengzhen Luo +9 more
doaj +2 more sources
Immunocastration with recombinant GnRH6-CRM197 fusion protein improves reproductive suppression and meat tenderness in roosters [PDF]
Poultry ScienceThis study evaluated the potential of the recombinant GnRH6-CRM197 fusion protein as an immunocastration vaccine for roosters. Forty 4-week-old roosters were divided into two groups: the immune group and the control group that received a saline injection.
Mengxian Li +12 more
doaj +2 more sources
Immunogenicity and Contraceptive Potential of a Classical Swine Fever Viral Vector Live Vaccine Strain Containing Pig Gonadotropin-Releasing Hormone [PDF]
VaccinesBackground: Classical swine fever virus (CSFV) is a highly contagious and fatal disease in pigs and wild boars. While hunting and bait vaccination are effective for CSFV eradication, additional strategies are needed to control wild boar populations. This
Dong-Jun An +8 more
doaj +2 more sources