Results 11 to 20 of about 357,265 (161)

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells. [PDF]

MedComm (2020)
HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosterone levels by desensitization of GnRHR, the downregulation of hTERT expression and telomerase activity, and the enhancement of Anticancer immunity.
Park JH, Lee JC, Sharma S, Jiang C, Lee H, Park HJ, Kim HS.   +6 more
europepmc   +2 more sources

The Effects of FSH Versus GnRH Vaccination on Growth Performance and Meat Quality of Surgically Castrated Male Growing-Finishing Pigs [PDF]

Animals
Previous studies have demonstrated that follicle-stimulating hormone (FSH) plays a critical role in promoting adipogenesis. Surgical castration results in elevated FSH concentrations in pigs, and is accompanied by reduced feed efficiency.
Ganchuan Wang, Junhua Zhou, Gang Lv, Xuemei Jiang, Chenling Song, Lun Hua, Chunxi Wang, Chao Jin, De Wu, Xingfa Han, Yong Zhuo   +10 more
doaj   +2 more sources

Safety and Therapeutic Profile of a GnRH-Based Vaccine Candidate Directed to Prostate Cancer. A 10-Year Follow-Up of Patients Vaccinated With Heberprovac

Frontiers in Oncology, 2019
Heberprovac is a GnRH based vaccine candidate containing 2.4 mg of the GnRHm1-TT peptide as the main active principle; 245 μg of the very small size proteoliposomes adjuvant (VSSP); and 350 μL of Montanide ISA 51 VG oil adjuvant.
Angel Cid-Arregui, Gerardo Guillen, Ricardo Bringas   +2 more
exaly   +3 more sources

Preparation of two kinds of immunocastration vaccines and their immune effects on male goats [PDF]

Animal Bioscience
Objective Post-pubertal male goats exhibit undesirable behaviors (fighting, mounting) and reduced growth due to high testosterone, while traditional castration causes stress. Immunocastration offers a humane alternative.
Fuqiang Pan, Yumeng Guo, Panpan Cheng, Wei Qian, Mengdi Han, Qing Yi, Huihui Xie, Meng Cao, Yanqiuhong Li, Yuke Jia, Jiankun Cui, Xinbao Gong, Ziye Zhu, Fugui Fang, Yinghui Ling, Yunsheng Li, Jian Li, Ya Liu   +17 more
doaj   +2 more sources

Effects of a Recombinant Gonadotropin-Releasing Hormone Vaccine on Reproductive Function in Adult Male ICR Mice

Vaccines, 2021
Gonadotropin-releasing hormone (GnRH) regulates the reproductive endocrine system in mammals. The GnRH immunocontraception vaccine can aid animal population control and management.
Ai-Mei Chang, Chen-Chih Chen, Ding-Liang Hou, Guan-Ming Ke, Jai-Wei Lee   +4 more
doaj   +1 more source

Palmitic acid-modified GnRH-Th epitope peptide immunocastration vaccine (W/O/W adjuvant) can effectively ensure the castration and reduce the smelly smell in boars

Frontiers in Veterinary Science, 2023
IntroductionRecent studies have demonstrated the effectiveness of Gonadotropin-releasing hormone (GnRH) in inhibiting testicular growth and development in male animals to achieve castration while improving the meat quality of various livestock species ...
Huayi Gao, Huayi Gao, Kun Liu, Lu Zhang, Yongfang Wang, Xubin Fu, Xubin Fu, Yujie Guo, Mei Bai, Yanbing Shen, Min Wang   +10 more
doaj   +1 more source

Delivering an Immunocastration Vaccine via a Novel Subcutaneous Implant

Animals, 2022
Immunocastration relies on the vaccine-mediated stimulation of an immune response to gonadotropin-releasing hormone (GnRH) in order to interrupt spermatogenesis. This approach offers a less painful alternative to traditional castration approaches but the
Andrew K. Curtis, Douglas E. Jones, Michael Kleinhenz, Shawnee Montgomery, Miriam Martin, Mikaela Weeder, Alyssa Leslie, Balaji Narasimhan, Sean Kelly, Drew R. Magstadt, Alfredo Colina, Johann F. Coetzee   +11 more
doaj   +1 more source

Effect of vaccination with a novel GnRH-based immunocontraceptive on immune responses and fertility in rats

Heliyon, 2020
1. As human-wildlife conflicts increase worldwide, novel methods are required for mitigating these conflicts. Fertility control, based on immunocontraceptives, has emerged as an alternative option to lethal methods for managing wildlife.2 ...
G. Massei, D. Cowan, D. Eckery, R. Mauldin, M. Gomm, P. Rochaix, F. Hill, R. Pinkham, L.A. Miller   +8 more
doaj   +1 more source

Immunocontraceptive potential of a GnRH receptor-based fusion recombinant protein

Journal of Genetic Engineering and Biotechnology, 2021
Background The management of stray dog population has been of utmost importance due to their overpopulation, increase in dog bites incidence, and rabies. Contraceptive vaccines, a non-surgical alternative to spaying and neutering are viewed as a valuable
Nathaniel Philip Sandam, Dhamodhar Prakash, Prashanth Thimmareddy   +2 more
doaj   +1 more source

Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]

, 2013
The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre, Liposits, Zsolt, Vastagh, Csaba, Sárvári, Miklós   +3 more
core   +3 more sources