Results 111 to 120 of about 1,476,050 (306)

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Serology change-based clinical interpretation of indeterminate serostatus post-hepatitis B virus infection in people living with HIV.

PLoS ONE
After hepatitis B virus (HBV) infection in people living with HIV (PLWH), various forms of indeterminate serostatuses, including "isolated anti-HBc (IAHBc)", are observed, but the current interpretation for their HBV immunity seems to be optimistic. This
Ei Kinai, Mio Ishikura, Ryui Miyashita, Tomoko Yamaguchi, Yushi Chikasawa, Akito Ichiki, Ryoko Sekiya, Masato Bingo, Takashi Muramatsu, Mihoko Yotsumoto, Takeshi Hagiwara, Kagehiro Amano   +11 more
doaj   +1 more source

ZAN 18

, 2009
Conclusie Het archeologisch onderzoek van het plangebied De Brede School te Kapel-Avezaath heeft een groot aantal sporen opgeleverd die hoofdzakelijk dateren vanaf de Karolingische tijd tot en met de Late Middeleeuwen.
Renswoude, drs. J. van (ACVU-HBS)
core   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

ZAN 8

, 2009
Conclusie In tegenstelling tot hetgeen werd verwacht op basis van het bureauonderzoek, zijn tijdens het veldonderzoek geen duidelijke aanwijzingen gevonden dat zich in het plangebied archeologische vindplaatsen bevinden. De archeologische indicatoren die
Verhelst, Drs. E.M.P. (ACVU-HBS), Boreel, Drs. G.L. (ACVU-HBS)   +1 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Evaluation of Serum Anti-Hbs Concentration in Children Vaccinated with Recombinant Hepatitis B Vaccine at Birth

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2006
Introduction: Vaccination with the major surface antigen of hepatitis B virus (HBsAg) induces anti-HBs antibody production and level of 10 IU/L is considered protective.
M Nejad-Ghaderi, A Mozafari, J Montazerifar, GH Hassanshahi, HR Rashidi-Nejad, A Jafarzadeh   +5 more
doaj  

Soroprevalência do vírus de hepatite B em anestesiologistas [PDF]

Revista Brasileira de Anestesiologia, 2003
JUSTIFICATIVA E OBJETIVOS: Os anestesiologistas estão particularmente expostos ao contato com sangue e secreções. A infecção pelo vírus da hepatite B constitui o maior risco ocupacional para os profissionais da área da saúde.
Antônio Fernando Carneiro, Roberto Ruhaman Daher   +1 more
doaj  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source