Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication
Current Topics in Medicinal Chemistry, 2019 The history of the human immunodeficiency virus (HIV)/AIDS therapy, which spans over 30 years, is one of the most dramatic stories of science and medicine leading to the treatment of a disease.
Kenji Maeda +4 more
semanticscholar +1 more source
Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]
, 2013 Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P. +12 more
core +2 more sources
Novel Antiretroviral Structures from Marine Organisms
Molecules, 2019 In spite of significant advancements and success in antiretroviral therapies directed against HIV infection, there is no cure for HIV, which scan persist in a human body in its latent form and become reactivated under favorable conditions.
Karlo Wittine +3 more
doaj +1 more source
Preparation of a Key Intermediate En Route to the Anti-HIV Drug Lenacapavir. [PDF]
J Org ChemCaravez JC +4 more
europepmc +3 more sources
Interaction of drugs of abuse and microRNA with HIV: a brief review. [PDF]
, 2015 MicroRNAs (miRNAs), the post-transcriptional regulators of gene expression, play key roles in modulating many cellular processes. The changes in the expression profiles of several specific miRNAs affect the interactions between miRNA and their targets in
Nair, Madhavan P.N. +1 more
core +2 more sources
Anti-HIV seropositivity among different group of patients; an observation from a secondary medical center in an endemic area of HIV infection [PDF]
Journal of Preventive Epidemiology, 2019 Human immunodeficiency virus (HIV) infection is an important medical problem worldwide. Since there is still no curative treatment, the good management for the HIV infected patient is necessary.
Pathum Sookaromdee, Viroj Wiwanitkit
doaj
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. [PDF]
PLoS ONE, 2014 The aim of this study is to explore the prevalence of hepatitis C virus (HCV) infection among injection drug users (IDUs) with and without human immunodeficiency virus (HIV) infection in southern Taiwan.
Meng-Hsuan Hsieh +13 more
doaj +1 more source
The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro
AIDS Research and Therapy, 2017 BackgroundPlant extracts are sources of valuable compounds with biological activity, especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a flavonoid found in several plants that has been described as an inhibitor
J. T. Ortega +5 more
semanticscholar +1 more source
Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies. [PDF]
PLoS ONE, 2010 We investigated the impact of antimicrobials in cervicovaginal lavage (CVL) from HIV(+) and HIV(-) women on target cell infection with HIV. Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CVL ...
Mimi Ghosh +10 more
doaj +1 more source
Characterization of Nanodiamond-based anti-HIV drug Delivery to the Brain
Scientific Reports, 2018 Human Immunodeficiency Virus Type 1 (HIV-1) remains one of the leading causes of death worldwide. Present combination antiretroviral therapy has substantially improved HIV-1 related pathology.
Upal Roy +9 more
semanticscholar +1 more source