Results 221 to 230 of about 295,334 (238)
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Physicochemical Properties of Carbovir, a Potential Anti-HIV Agent
Journal of Pharmaceutical Sciences, 1990(+-)-Carbovir [(+-)-9-[4 alpha-(hydroxymethyl)-cyclopent-2-ene-1 alpha-yl]guanine; NSC 614846] is a novel carbocyclic nucleoside analogue which has been shown to be a potent and selective inhibitor of HIV in vitro. As part of an effort to develop a parenteral formulation for subsequent clinical and toxicological evaluation of this compound, the aqueous
Chin-Yun Chiang, Bradley D. Anderson
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Further characterization of sulfated homopolysaccharides as anti-HIV agents
Experientia, 1989Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT) activity by interacting with the HIV envelope in the membranes of target cells. Furthermore, they showed a synergistic effect with azidothymidine (AZT).
W. Itoh +4 more
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Marine Natural Products as Lead Anti-HIV Agents
Mini-Reviews in Medicinal Chemistry, 2003Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.
D J, Gochfeld +11 more
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A Review on Quinoline Derived Scaffolds as Anti-HIV Agents
Mini-Reviews in Medicinal Chemistry, 2019After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable anti-HIV agents, as existing medicines do not provide a complete cure and exhibit drawbacks like toxicities, drug resistance, side ...
Sourav Kalra +3 more
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Design and Development of Integrase Inhibitors as Anti-HIV Agents
Current Medicinal Chemistry, 2003A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds ...
Anantha Naik Nagappa, S.P. Gupta
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Plant-derived Terpenoids and Analogues as Anti-HIV Agents
Current Topics in Medicinal Chemistry, 2003The plant-derived terpenoids and analogues are reviewed with respect to their anti-HIV activity, structure-activity relationships, and mechanism of action. The active compounds include diterpenoid lactones, phenolic diterpenes, atisane and kaurane diterpenes, phorbol diterpenes, triterpene glycosides, friedelane triterpenes, taraxerane triterpenes ...
Susan L. Morris-Natschke +3 more
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New nordihydroguaiaretic acid derivatives as anti-HIV agents
Bioorganic & Medicinal Chemistry Letters, 2008Reaction of nordihydroguaiaretic acid with various alkyl chloride, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1'-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respectively, in 67-83% yields.
Ming-Hua Hsu +3 more
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Recent Studies on Natural Products as Anti-HIV Agents
Current Medicinal Chemistry, 2000The discovery of medicinal agents capable of specifically inhibiting human immunodeficiency virus (HIV) is urgently needed due to its globally widespread infection. Most of clinically useful anti-HIV agents are nucleosides but their use is limited due to their severe toxicity and emerging drug resistance.
Mankil Jung +3 more
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Researchers Explore New Anti-HIV Agents
JAMA, 2002SEATTLE—While antiretroviral drugs have done much to extend the lives of people infected with HIV, severe adverse effects and rising levels of drug resistance can limit their usefulness and are driving efforts to develop new antiHIV medications. Building on knowledge of HIV gleaned from laboratory studies of the virus, researchers are developing and ...
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Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents
Combinatorial Chemistry & High Throughput Screening, 2005Selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204 microM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in ...
Ravindra K. Rawal +4 more
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