Results 231 to 240 of about 2,671,914 (293)

Evolution of CAR‐T Therapy: Functional Engineering, Manufacturing Innovation, and Future In Vivo Strategies

Cancer Science, EarlyView.
CAR‐T therapy is evolving across four interconnected dimensions: functional engineering, manufacturing innovation, alternative cell sources, and in vivo CAR programming. Together, these advances address limitations in therapeutic efficacy, safety, manufacturing complexity, scalability, and accessibility, providing complementary paths toward the next ...
Yukimi Sakoda
wiley   +1 more source

iPSC‐Derived iNK Progenitors Engraft and Generate NK Cells in Unconditioned and Autologous Immune Humanized Mice

Cell Proliferation, EarlyView.
Infusion of CXCR4‐expressing iNK progenitor (iNKP) cells derived from iPSCs can continuously generate iNK cells in an unconditioned and autologous PBMC humanised hIL15 mouse model. iNKP cell therapy has the potential to treat patients without the requirement for prior lymphodepletion. ABSTRACT NK cells exhibit inherently short persistence in vivo. Allo‐
Min Zhang, Zhiqian Wang, Yanhong Liu, Leqiang Zhang, Fangxiao Hu, Chengxiang Xia, Mengyun Zhang, Tongjie Wang, Qitong Weng, Hanmeng Qi, Yanping Zhu, Lijuan Liu, Dehao Huang, Hong‐Hu Zhu, Jinyong Wang   +14 more
wiley   +1 more source

Human Embryonic Stem Cell‐Derived Immunity‐And‐Matrix‐Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1‐Mediated Collagen Degradation

Cell Proliferation, EarlyView.
Human embryonic stem cell‐derived Immunity‐and‐Matrix‐Regulatory Cells (IMRCs) effectively attenuate pulmonary fibrosis by secreting Matrix Metalloproteinase‐1 (MMP1), which directly degrades excess collagen I in the extracellular matrix. By directly degrading collagen I, IMRCs reverse ECM stiffness, suppress myofibroblast activation, and promote a ...
Zhongwen Li, Dingyun Song, Faguo Sun, Licheng Song, Bin An, Tingting Gao, Jingjing Liu, Kan Zhang, Kaidi Liu, Kaiwei Wu, Yajing Li, Yi Yang, Yaru Liu, Ruofan Su, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liang Peng, Liu Wang, Wei Li, Lixin Xie, Jie Hao, Huaping Dai, Jun Wu   +24 more
wiley   +1 more source

Fibrillar‐Type Dermatitis Herpetiformis: An Underrecognized Variant That Is Rarely Associated With Celiac Disease and Lacking Epidermal Transglutaminase Deposition: A Report of Two Cases

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Dermatitis herpetiformis (DH) is a rare, intensely pruritic cutaneous manifestation of celiac disease (CD), typically presenting with excoriated papulovesicular lesions on extensor surfaces. DH is associated with IgA autoantibodies against epidermal transglutaminase (eTG), which form granular immune deposits in the papillary dermis and induce ...
Jeffrey Damman, Elodie Mendels, Sven van der Woude, Sharon Veenbergen, Gilles F. H. Diercks, Martijn B. van Doorn   +5 more
wiley   +1 more source

HLA allele DRB1*01:03: the genetic link to neutralizing IL-10 antibodies in inflammatory bowel disease. [PDF]

Signal Transduct Target Ther
Mattner J.
europepmc   +1 more source

Immune effector cell‐associated neurotoxicity syndrome (ICANS) during tebentafusp in metastatic uveal melanoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Laura Schreieder, Laura Jockel, Veronika Zenderowski, Ralf A. Linker, Sebastian Haferkamp, Elisabeth Bumes, Peter Hau, Konstantin Drexler   +7 more
wiley   +1 more source

Immunogenicity of Anti-HLA Antibodies in Pancreas and Islet Transplantation [PDF]

Cell Transplantation, 2016
The aim of the current study was to characterize the anti-HLA antibodies before and after pancreatic islet or pancreas transplantation. We assessed the risk of anti-donor-specific antibody (DSA) sensitization in a single-center, retrospective clinical ...
Benjamin Chaigne, Eric Spierings, Kirsten Geneugelijk   +2 more
exaly   +9 more sources

IgM Anti-Idiotypes That Block Anti-HLA Antibodies: Naturally Occurring or Immune Antibodies?

Clinical and Experimental Immunology, 1991
SUMMARY Using dithiothreitol (DTT) technique, IgM anti-HLA anti-idiotypic antibodies were detected in a multiparous multitransfused woman.
M M Tongio, A Urlacher, J L Pasquali
exaly   +2 more sources

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Pretransplant Anti-HLA-Cw and Anti-HLA-DP Antibodies in Sensitized Patients

Human Immunology, 2012
We investigated the prevalence and the strength of anti-HLA-Cw and DP antibodies and clinical outcomes in kidney transplant recipients with isolated donor-specific anti-HLA-Cw antibodies. Patients on the waiting list were screened by Luminex single antigen beads (One Lambda). The strength of antibodies was determined by mean fluorescence intensity (MFI)
Liise K Kayler, Kwaku Marfo, Graciela de Boccardo   +2 more
exaly   +3 more sources

Anti-HLA antibodies in heart transplantation

Transplant Immunology, 2004
We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a). number of HLA mismatches between recipient and donor; (b). production of anti-HLA antibodies; (c). growth of lymphocytes infiltrating the graft; and (d).
Elena R, Vasilescu, Eric K, Ho, Ludwika, de la Torre, Silviu, Itescu, Charles, Marboe, Raffaello, Cortesini, Nicole, Suciu-Foca, Donna, Mancini   +7 more
openaire   +2 more sources