Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]
, 2011 The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong +7 more
core +2 more sources
Synthesis and characterization of anti-infective agents [PDF]
, 2019 Antifungal chemotherapy depends on bio-chemical alterations between fungi and mammals. Unlike bacteria, which are prokaryotes, both fungi and mammals are eukaryotes and the biochemical differences between them are not significant. However, there are some
Arora, Neha +5 more
core +3 more sources
Anti-infective and anti-cancer properties of the Annona species: their ethnomedicinal uses, alkaloid diversity, and pharmacological activities [PDF]
, 2019 Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for
Damayanti, Yuvita Dian +3 more
core +1 more source
Stability of bacteriophages in burn wound care products [PDF]
, 2017 Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound ...
De Vos, Daniel +8 more
core +9 more sources
Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics [PDF]
, 2009 Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance.
Bernardini, F +6 more
core +1 more source
Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]
, 2016 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core +1 more source
Cooperative and Competitive Biases for Multi-Agent Reinforcement Learning [PDF]
arXiv, 2021 Training a multi-agent reinforcement learning (MARL) algorithm is more challenging than training a single-agent reinforcement learning algorithm, because the result of a multi-agent task strongly depends on the complex interactions among agents and their interactions with a stochastic and dynamic environment.
arxiv
Fact-based Agent modeling for Multi-Agent Reinforcement Learning [PDF]
arXiv, 2023 In multi-agent systems, agents need to interact and collaborate with other agents in environments. Agent modeling is crucial to facilitate agent interactions and make adaptive cooperation strategies. However, it is challenging for agents to model the beliefs, behaviors, and intentions of other agents in non-stationary environment where all agent ...
arxiv
Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa [PDF]
, 2015 The treatment of chronic Pseudomonas aeruginosa infections is challenging, with resistance and antibiogram diversity accumulating during successive therapies.
Andrews +9 more
core +1 more source
Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials [PDF]
, 2018 This is a post-peer-review, pre-copyedit version of an article published in Applied microbiology and biotechnology The final authenticated version is available online at: http://dx.doi.org/10.1007/s00253-018-8776-0Drug resistance occurrence is a global ...
Bassegoda Puigdomenech, Arnau +3 more
core +2 more sources