The Pharmacological Potential of Mushrooms [PDF]
, 2005 This review describes pharmacologically active compounds from mushrooms. Compounds and complex substances with antimicrobial, antiviral, antitumor, antiallergic, immunomodulating, anti-inflammatory, antiatherogenic, hypoglycemic, hepatoprotective and ...
Jülich, Wolf-Dieter +2 more
core +3 more sources
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]
, 2016 Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M +11 more
core +2 more sources
Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
Behavioral and Brain Functions, 2023 Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD).
Xuewang Li +7 more
doaj +1 more source
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice
Journal of Ginseng Research, 2021 Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer’s disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still ...
Han Zhang +10 more
doaj +1 more source
The application of HER2 and CD47 CAR-macrophage in ovarian cancer
Journal of Translational Medicine, 2023 Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen +17 more
doaj +1 more source
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis
Mediators of Inflammation, 2020 Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue ...
Dan Mei +3 more
doaj +1 more source
Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice
Renal Failure, 2023 Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but
Pengmin Ji +8 more
doaj +1 more source
New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation [PDF]
, 2013 Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor family of ...
Dejager, Lien +3 more
core +1 more source
Mediators of Inflammation, 2018 MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong +4 more
doaj +1 more source
Long non-coding RNAs: Potential therapeutic targets for epilepsy
Frontiers in Neuroscience, 2022 Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide.
Sen Liu +14 more
doaj +1 more source