Results 41 to 50 of about 5,289,236 (296)

Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice

Journal of Ginseng Research, 2021
Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer’s disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still ...
Han Zhang, Yong Su, Zhenghao Sun, Ming Chen, Yuli Han, Yan Li, Xianan Dong, Shixin Ding, Zhirui Fang, Weiping Li, Weizu Li   +10 more
doaj   +1 more source

Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice

Renal Failure, 2023
Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but
Pengmin Ji, Qifeng Shi, Yan Liu, Min Han, Yong Su, Ran Sun, Huimin Zhou, Weizu Li, Weiping Li   +8 more
doaj   +1 more source

Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications

Therapeutic Advances in Endocrinology and Metabolism
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as promising therapeutic agents with potent anti-inflammatory properties and diverse clinical implications.
S. Alharbi
semanticscholar   +1 more source

Targeting immunometabolism as an anti-inflammatory strategy

Cell Research, 2020
The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic precursors, but are also a way of controlling immunity and inflammation.
E. Palsson-McDermott, L. O’Neill
semanticscholar   +1 more source

The role of a key transcription factor PU.1 in autoimmune diseases

Frontiers in Immunology, 2022
PU.1, a transcription factor member of the E26 transformation-specific family, affects the function of a variety of immune cells in several physiological and pathological conditions.
Yilong Fang, Weile Chen, Zhe Li, Yu Chen, Xuming Wu, Xiangling Zhu, Huihui Wang, Xiaochun Chen, Qiuni Liang, Jinghua Huang, Xintong Han, Wenming Hong, Xinming Wang, Wei Wei, Zhiying Yu, Jiajie Tu   +15 more
doaj   +1 more source

The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

Mediators of Inflammation, 2018
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong, Pengying Zhang, Xinming Wang, Jiajie Tu, Wei Wei   +4 more
doaj   +1 more source

Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review

Tropical Medicine and Infectious Disease
Interleukins (ILs) are signaling molecules that are crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of immune cells, whereas anti-inflammatory ILs help to suppress ...
A. Al-Qahtani, F. Alhamlan, A. Al-Qahtani   +2 more
semanticscholar   +1 more source

The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis

Advances in wound care, 2020
Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue results in a loss of structural integrity and function, with ...
Emily H. Steen, Xinyi Wang, S. Balaji, M. Butte, P. Bollyky, S. Keswani   +5 more
semanticscholar   +1 more source

Long non-coding RNAs: Potential therapeutic targets for epilepsy

Frontiers in Neuroscience, 2022
Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide.
Sen Liu, Sen Liu, Sen Liu, Min Fan, Min Fan, Min Fan, Meng-Die Ma, Meng-Die Ma, Meng-Die Ma, Jin-Fang Ge, Jin-Fang Ge, Jin-Fang Ge, Fei-Hu Chen, Fei-Hu Chen, Fei-Hu Chen   +14 more
doaj   +1 more source

Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice

Journal of Ginseng Research, 2023
Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined.
Xianan Dong, Liangliang Kong, Lei Huang, Yong Su, Xuewang Li, Liu Yang, Pengmin Ji, Weiping Li, Weizu Li   +8 more
doaj   +1 more source