Results 141 to 150 of about 1,883,497 (302)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

PHYTOCHEMICALS, NUTRITIONAL AND ANTI-NUTRITIONAL COMPOSITION OF ETHANOL LEAVES EXTRACT OF ELEUSINE INDICA

Journal of Experimental and Molecular Biology
Eleusine indica has been consumed for nutrition and management of many diseases including epilepsy, diarrhea, infections, dysentery, influenza, and hypertension. This study aimed at evaluating the phytochemicals, nutrients and anti-nutrients composition
Ibrahim Abubakar, Shehu Ibrahim, Nusaiba Lawan Ahmad   +2 more
doaj   +3 more sources

The Germination Paradox in Sorghum: A Review

Foods
Sorghum (Sorghum bicolor L. Moench) is a climate-resilient cereal with significant potential as a functional food due to its distinctive polyphenolic profile, including rare 3-deoxyanthocyanidins (3-DXAs). Broader utilisation of sorghum is limited by low
Yogita Sharma, Nidhish Francis, Christopher Blanchard, Abishek Bommannan Santhakumar   +3 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Effect of processing on the nutritional and anti-nutritional content of improved sorghum (Sorghum Bicolor L. Moench) breeds as a teff (eragrostis teff) substitute in injera making

Cogent Food & Agriculture
Teff, a gluten-free grain, is a staple in Ethiopian cuisine, primarily used to make injera. Recently, underutilized crops like sorghum have gained increased interest in the injera production. The goal of this study is to evaluate the effect of processing
Abrehet F. Gebremeskel, Getahun Adane, Kebede Abegaz   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Nutrient and Anti-Nutrient Content of Wheat-Cassava Composite Flour

This study evaluated the nutrient and anti-nutrient properties of wheat-cassava composite flour. Composite flour of cassava and wheat were blended into different ratios and analysed for nutrients and anti-nutrient properties.
Nwachukwu, C. A, Enyi, C. U, Ogbedeagu, C. O, Arukwe, D. C   +3 more
openaire   +1 more source

The Effect of Boiling on the Nutrients and Anti-Nutrients in Two non Conventional Vegetables

Pakistan Journal of Nutrition, 2009
The effect of boiling on the nutrient and anti-nutrient composition of two vegetables Solanum nigrum and Solanecio biafrae was investigated. The vegetables were boiled and the boiled and raw samples were analysed for proximate composition and some anti nutritional compounds.
openaire   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source