Results 21 to 30 of about 330,161 (260)

Obesity Drug Update: The Lost Decade?

Pharmaceuticals, 2010
The growing worldwide obesity epidemic and obesity-related disorders present a huge unmet medical need for safe and effective anti-obesity medications. The discovery of leptin in 1994 was rapidly succeeded by a wave of related discoveries leading to the ...
Fayi Yao, Robert George MacKenzie
doaj   +1 more source

Effects of Fermented Citrus Peel on Ameliorating Obesity in Rats Fed with High-Fat Diet

Molecules, 2022
Although citrus peel is a waste material, it contains a variety of bioactive components. As our preliminary findings showed that citrus peels fermented with Saccharomyces cerevisiae T1 contained increased levels of anti-obesity flavonoids, the objective ...
Chung-Hsiung Huang, Shun-Yuan Hsiao, Yung-Hsiang Lin, Guo-Jane Tsai   +3 more
doaj   +1 more source

Tocotrienols Attenuate White Adipose Tissue Accumulation and Improve Serum Cholesterol Concentration in High-Fat Diet-Treated Mice

Molecules, 2022
Tocotrienols (T3s), which are vitamin E homologs, have not only antioxidant function but also inhibitory effects on body weight gain and hepatic lipid droplet accumulation. However, the mechanisms of the anti-obesity effects of T3s are not yet understood.
Yugo Kato, Yoshinori Aoki, Chikako Kiyose, Koji Fukui   +3 more
doaj   +1 more source

Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms

Food Science and Human Wellness
Obesity has become a signifi cant global public health issue. Previous studies have found that the Chenpi has the anti-obesity activity. However, the anti-obesity phytochemicals and their mechanisms are still unclear.
Jinhai Luo, Weiqi Yan, Zhi Chen, Baojun Xu   +3 more
doaj   +1 more source

Research Progress on Anti Obesity Effects of Tea Polyphenols

Shipin gongye ke-ji
Obesity is a major risk factor and pathological basis for several chronic diseases such as diabetes, cardiovascular diseases, and tumors. It has now become a global public health issue.
Fei WANG, Shuxun YAN, Ping WANG
doaj   +1 more source

Antioxidant, Anti-Obesity, Nutritional and Other Beneficial Effects of Different Chili Pepper: A Review

Molecules, 2022
Fruits and vegetables are important components of a healthy diet. They are rich sources of vitamins and minerals, dietary fibre and a host of beneficial non-nutrient substances including plant sterols, flavonoids and other antioxidants.
Azrina Azlan, Sharmin Sultana, Chan Suk Huei, Muhammad Rizal Razman   +3 more
doaj   +1 more source

Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking

International Journal of Food Properties
Recently, the global epidemic of obesity is increasing significantly. Obesity is treated with anti-obesity medications and surgery and complications related to these treatments prompt the search of phytochemicals that confer anti-obesity effects ...
Yongxiang Liu, Jinhai Luo, Maninder Meenu, Baojun Xu   +3 more
doaj   +1 more source

Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells

Applied Sciences, 2021
Our study investigated that the anti-obesity effect of the Trapa japonica Flerov extract (TJ) in differentiated 3T3-L1 adipocytes. To this end, 3T3-L1 cells were treated with TJ during their differentiation period. On the last day of the cell culture, we
Soo-Jeung Park, Minhee Lee, Ki-Young Kim, Su Shin, Min-Woo Choi, Eun-Jin Hong, Jeongmin Lee   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Revealing Molecular Mechanisms of the Bioactive Saponins from Edible Root of Platycodon grandiflorum in Combating Obesity

Plants
Obesity has emerged as a significant health concern, as it is a disease linked to metabolic disorders in the body and is characterized by the excessive accumulation of lipids.
Bincheng Han, Jinhai Luo, Baojun Xu
doaj   +1 more source