Results 81 to 90 of about 49,611 (279)
BRIVA‐ONE study: 12‐month outcomes of brivaracetam monotherapy in clinical practice
Epilepsia OpenObjective This study investigated the effectiveness and tolerability of brivaracetam (BRV) monotherapy in a large series of patients with epilepsy. Method This was a multicenter, retrospective, observational, non‐interventional study in 24 hospitals ...
Vicente Villanueva +30 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Adherence to secondary stroke prevention strategies - Results from the German stroke data bank [PDF]
, 2003 Only very limited data are available concerning patient adherence to antithrombotic medication intended to prevent a recurrent stroke. Reduced adherence and compliance could significantly influence the effects of any stroke prevention strategies.
Diener, H. C. +4 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The association between periodontal disease and seizure severity in refractory epilepsy patients
, 2015 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Purpose: Periodontal diseases are common in most populations and affect people at all socioeconomic levels.
Yasuda, CL +6 more
core +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Epidemiology and clinical characteristics of epilepsy patients in a tertiary care hospital in Egypt
The Egyptian Journal of Neurology, Psychiatry and NeurosurgeryBackground Epilepsy is a major neurological disorder with variable etiologies, clinical presentations, and treatment outcomes. In resource-limited settings, restricted access to diagnostic facilities often hinders accurate classification and optimal ...
Mona Wahid El Din +4 more
doaj +1 more source
Is it the Remedy or the Disease? Psychiatric Symptoms Related to Anti-Seizure Medications [PDF]
Epilepsy Currents, 2018 [Box: see text]
openaire +2 more sources