Results 51 to 60 of about 44,733 (219)

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, EarlyView.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

Transcriptomic basis for an antiserum against Micrurus corallinus (coral snake) venom [PDF]

, 2009
Background Micrurus corallinus (coral snake) is a tropical forest snake belonging to the family Elapidae. Its venom shows a high neurotoxicity associated with pre- and post-synaptic toxins, causing diaphragm paralysis, which may result in death. In spite
Luciana I Leão, Paulo L Ho, Inacio de LM Junqueira-de-Azevedo   +2 more
core   +2 more sources

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Rosemary leaves extract: Anti-snake action against Egyptian Cerastes cerastes venom

Journal of Traditional and Complementary Medicine, 2018
The morbidity caused by viper bites is very dangerous and the anti-venom therapy couldn't treat the local injures such as hemorrhage, edema, necrosis and inflammation of bitten tissues. Searching for safe and effective anti-venom compounds from natural sources is very important.
Walaa H. Salama, Azza M. Abdel-Aty, Afaf S. Fahmy   +2 more
openaire   +3 more sources

Low-level laser therapy decreases local effects induced by myotoxins isolated from Bothrops jararacussu snake venom [PDF]

, 2010
The prominent myotoxic effects induced by Bothrops jararacussu crude venom are due, in part, to its polycationic myotoxins, BthTX-I and BthTX-II. Both myotoxins have a phospholipase A2 structure: BthTX-II is an active enzyme Asp-49 PLA2, while BthTX-I is
BARBOSA, AM, COGO, JC, GUIMARÃES-SOUSA, L, SOARES, AM, VILLAVERDE, AB, ZAMUNER, SF, ZAMUNER, SR   +6 more
core   +2 more sources

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A [PDF]

, 2009
Background It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA2 provoke inflammation remain unclear.
Ji-Fu Wei, Xiao-Long Wei, Ya-Zhen Mo, Shao-Heng He   +3 more
core   +2 more sources

Shortcomings in snake bite management in rural Cameroon: a case report

BMC Research Notes, 2017
Background Snake bites are an important public health problem in developing countries with most bites occurring in rural areas. Severe envenomation often occurs in children and following bites to the face.
Frank-Leonel Tianyi, Christian Akem Dimala, Vitalis Fambombi Feteh   +2 more
doaj   +1 more source

The effect of a serum containing acetyl hexapeptide‐8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies

International Journal of Cosmetic Science, EarlyView.
The novel serum demonstrates significant anti‐skin aging effects, effectively improving static and dynamic wrinkles and skin texture. Therefore, this formulation holds promise as a safe and effective product in the field of anti‐wrinkle skincare products.
Mingjie Zhu, Xiaofeng He, Zailing Zhu, Stephen Lynch, Hequn Wang, Xiaoyin Zhou, Yidong Tu, Andrew Steel, Kung Chi Hsu, Yueqing Niu, Anna Cho, Mutsue Hashimoto, Xi Yan, Maggie Su, Wenna Wang   +14 more
wiley   +1 more source