Results 1 to 10 of about 9,255 (180)

Impact of Naja nigricollis Venom on the Production of Methaemoglobin [PDF]

Toxins, 2018
Snakebite envenomation is an affliction currently estimated to be killing upwards of 100,000 people annually. Snakebite is associated with a diverse pathophysiology due to the magnitude of variation in venom composition that is observed worldwide.
Harry F. Williams, Paul Hayter, Divyashree Ravishankar, Anthony Baines, Harry J. Layfield, Lorraine Croucher, Catherine Wark, Andrew B. Bicknell, Steven Trim, Sakthivel Vaiyapuri   +9 more
doaj   +9 more sources

Non-compartmental toxicokinetic studies of the Nigerian Naja nigricollis venom [PDF]

Toxicon: X, 2022
Snakebite envenoming (SBE) is a neglected public health problem, especially in Asia, Latin America and Africa. There is inadequate knowledge of venom toxicokinetics especially from African snakes.
Auwal A. Bala, Sani Malami, Yusuf Abubakar Muhammad, Binta Kurfi, Ismaila Raji, Sanusi Muhammad Salisu, Mustapha Mohammed, George Oche Ambrose, Murtala Jibril, Jacob A. Galan, Elda E. Sanchez, Basheer A.Z. Chedi   +11 more
doaj   +6 more sources

Kolaviron alleviates haematological abnormalities and hepato-renal damage in Naja nigricollis nigricollis venom-treated rats [PDF]

Toxicology Reports, 2022
Objectives: To investigate the effect of kolaviron against haematological abnormalities and hepato-renal damage in Naja n. nigricollis (NNN) venom-treated rats. Methods: Twenty-four male rats were grouped into four (n = 6).
Azubuike Ikechukwu Okafor, Ndika Ndika Ogban, Anthonia Amarachi Odinigwe   +2 more
doaj   +5 more sources

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib [PDF]

Toxins, 2021
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites.
Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool   +7 more
doaj   +4 more sources

Naja nigricollis venom altered reproductive and neurological functions via modulation of pro-inflammatory cytokines and oxidative damage in male rats [PDF]

Metabolism Open, 2022
Reproductive and neurological anomalies are often characterized by malfunctioning of reproductive and nervous organs sometimes attributed to systemic toxins.
Babafemi Siji Ajisebiola, Olukemi Blessing Adeniji, Adewale Segun James, Babajide O. Ajayi, Akindele Oluwatosin Adeyi   +4 more
doaj   +3 more sources

Comparative Label-Based Proteomics of Venoms from Echis ocellatus, Naja nigricollis, and Bitis arietans [PDF]

Proteomes
Background: Snake envenomation is a major public health issue in Nigeria, primarily due to bites from Echis ocellatus, Naja nigricollis, and Bitis arietans. Understanding their venom composition is essential for effective antivenom development.
Abdulbaki Alfa-Ibrahim Adio, Samuel Odo Uko, Jiddah Muhammad Lawal, Ibrahim Malami, Nafiu Lawal, Amina Jega Yusuf Jega, Bilyaminu Abubakar, Muhammad Bashir Bello, Kasimu Ghandi Ibrahim, Murtala Bello Abubakar, Abdussamad Muhammad Abdussamad, Mujtaba Sulaiman Abubakar, Mustapha Umar Imam   +12 more
doaj   +3 more sources

Black-necked spitting cobra (Naja nigricollis) phospholipases A2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket [PDF]

Scientific Reports, 2022
African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane is covered by
Andrea Martos-Esteban, Olivia J. S. Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A. Jürgensen, Mark Carrington, Andreas H. Laustsen   +6 more
doaj   +8 more sources

Preliminary Insights into Geographic Variation in Venom Profiles and Functional Activities of Nigerian Snakes, Bitis arietans and Naja nigricollis [PDF]

Toxins
Snakebite envenoming is a major yet neglected tropical disease in sub-Saharan Africa, where antivenom efficacy is critically limited by intraspecific venom variation shaped by local ecological pressures. Nigeria’s sharply contrasting Sudan Savanna (North)
Akindele Oluwatosin Adeyi, Oluwatimilehin Stephen Emmanuel, Samuel Itang Itang, Babafemi Siji Ajisebiola, Mihir Kumar, Gotravalli V. Rudresha, Prasad Gopalkrishna Gond, Thomas Crasset, Damien Redureau, Fernanda Gobbi Amorim, Kartik Sunagar, Loïc Quinton   +11 more
doaj   +2 more sources

Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae) [PDF]

Toxicon: X, 2020
Four peptides with cytotoxic activity against BRIN-BD11 rat clonal β-cells were purified from the venom of the black-necked spitting cobra Naja nigricollis using reversed-phase HPLC. The peptides were identified as members of the three-finger superfamily
J.M. Conlon, Samir Attoub, Vishal Musale, Jérôme Leprince, Nicholas R. Casewell, Libia Sanz, Juan J. Calvete   +6 more
doaj   +2 more sources

A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom [PDF]

Toxicon: X
Recent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP ...
Andrés Sánchez, Gina Durán, Maykel Cerdas, Jairo Gutiérrez, Álvaro Segura, María Herrera, Mariángela Vargas, Adriana Sánchez, Paola Sánchez, Gabriela Solano, Mauren Villalta, Edwin Moscoso, Deibid Umaña, Mauricio Arguedas, Aarón Gómez, José María Gutiérrez, Guillermo León   +16 more
doaj   +2 more sources