Results 11 to 20 of about 18,183 (205)

Pharmacological intervention: Challenges and promising outcomes for fat loss and preservation of lean body mass in the treatment of overweight and type 2 diabetes. [PDF]

Diabetes Obes Metab
Abstract Treatment with GLP‐1 receptor agonists (GLP‐1 RAs) is effective in reducing body weight in individuals with overweight and type 2 diabetes (T2D). However, measurements indicate that a considerable portion of the weight loss derives from fat‐free mass (FFM), including skeletal muscle, which may compromise metabolic health and physical function.
Aimelet V, Holst JJ.
europepmc   +2 more sources

1,3,4-Oxadiazole Contained Sesquiterpene Derivatives: Synthesis and Microbiocidal Activity for Plant Disease

Frontiers in Chemistry, 2022
A series of 1,3,4-oxadiazole contained sesquiterpene derivatives were synthesized, and the activity of the target compounds against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis pv. citri (Xac), and tobacco mosaic virus (TMV) were evaluated.
Ali Dai, Zhiguo Zheng, Lijiao Yu, Yuanqin Huang, Jian Wu   +4 more
doaj   +1 more source

First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against tobacco mosaic virus (TMV). [PDF]

PLoS ONE, 2012
A series of phenanthroquinolizidine alkaloids 1-24 were prepared and first evaluated for their antiviral activity against tobacco mosaic virus (TMV). The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV ...
Ziwen Wang, Anzheng Feng, Mingbo Cui, Yuxiu Liu, Lizhong Wang, Qingmin Wang   +5 more
doaj   +1 more source

The curative activity of some arylidene dihydropyrimidine hydrazone against Tobacco mosaic virus infestation

Journal of Saudi Chemical Society, 2022
A series of novel pyrimidine-based derivative compounds were synthesized and evaluated for antiviral activity against Tobacco mosaic virus (TMV).
Alaa Z. Omar, Esraa Hamdy, Ezzat A. Hamed, Elsayed Hafez, Ahmed Abdelkhalek   +4 more
doaj   +1 more source

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues

Molecules, 2023
Compounds with acylhydrazone fragments contain amide and imine groups that can act as electron donors and acceptors, so they are easier to bind to biological targets and thus generally exhibit significant biological activity.
Wanjun Ni, Hongjian Song, Lizhong Wang, Yuxiu Liu, Qingmin Wang   +4 more
doaj   +1 more source

Discovery of Cysteine and Its Derivatives as Novel Antiviral and Antifungal Agents

Molecules, 2021
Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by 1H-NMR, 13C-NMR, and HRMS techniques. The
Shan Yang, Tienan Wang, Yanan Zhou, Li Shi, Aidang Lu, Ziwen Wang   +5 more
doaj   +1 more source

Xanthones from the herb of Swertia elata and their anti-TMV activity [PDF]

Natural Product Research, 2015
Two new xanthones (1–2), together with four known ones (3–6), were isolated from whole herb of Swertia elata. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Their anti-tobacco mosaic virus (anti-TMV) activity test revealed that 1–6 showed weak anti-TMV activities with inhibition rate in the ...
Wei, Jiang, Dong-Lai, Zhu, Ming-Feng, Wang, Qing-Song, Yang, Ma-Yi, Zuo, Liang, Zeng, Gan-Peng, Li   +6 more
openaire   +2 more sources

Research on the Interaction Mechanism Between α Mino-Phosphonate Derivative Q-R and Harpin-Binding Protein 1 in Tobacco (Nicotiana tabacum) Plants

Frontiers in Microbiology, 2021
Amino-phosphonate derivative R-diphenyl-1-(4-methylbenzothiazole-2-amino)-1-(thiphene-2-yl)-methylphosphonate (Q-R) has a high protective anti-tobacco mosaic virus (TMV) activity.
Maoxi Huang, Yunlong Yan, Yunlong Yan, Li Wang, Li Wang, Jun Chen, Jun Chen, Tao Liu, Xin Xie, Xiangyang Li   +9 more
doaj   +1 more source

Design, synthesis, and antiviral activities evaluation of novel quinazoline derivatives containing sulfonamide moiety

Heterocyclic Communications, 2023
A series of novel quinazoline derivatives bearing sulfonamide moiety was designed and synthesized, and their structure were characterized by 1H NMR, 13C NMR, and HRMS techniques.
Deng Yi, Yin Shitao, Jing Xinyun, Zheng Yuguo   +3 more
doaj   +1 more source

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT NK0238 [PDF]

Frontiers of Agricultural Science and Engineering, 2022
<List> <ListItem><ItemContent><p>• Developed a two-step synthetic route to anti-plant-virus candidate NK0238.</p></ItemContent></ListItem> <ListItem><ItemContent><p>• NK0238 ...
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
doaj   +1 more source